Proteostasis of islet amyloid polypeptide: a molecular perspective of risk factors and protective strategies for type II diabetes
The possible link between hIAPP accumulation and β-cell death in diabetic patients has
inspired numerous studies focusing on amyloid structures and aggregation pathways of this …
inspired numerous studies focusing on amyloid structures and aggregation pathways of this …
[HTML][HTML] Amyloid growth and membrane damage: Current themes and emerging perspectives from theory and experiments on Aβ and hIAPP
Alzheimer's Disease (AD) and Type 2 diabetes mellitus (T2DM) are two incurable diseases
both hallmarked by an abnormal deposition of the amyloidogenic peptides Aβ and Islet …
both hallmarked by an abnormal deposition of the amyloidogenic peptides Aβ and Islet …
Stabilizing off-pathway oligomers by polyphenol nanoassemblies for IAPP aggregation inhibition
Experimental studies have shown that many naturally occurring polyphenols have inhibitory
effect on the aggregation of several proteins. Here, we use discrete molecular dynamics …
effect on the aggregation of several proteins. Here, we use discrete molecular dynamics …
Role of aromatic amino acids in amyloid self-assembly
Amyloids are proteins of a cross-β structure found as deposits in several diseases and also
in normal tissues (nails, spider net, silk). Aromatic amino acids are frequently found in …
in normal tissues (nails, spider net, silk). Aromatic amino acids are frequently found in …
The role of cholesterol in driving IAPP-membrane interactions
Our knowledge of the molecular events underlying type 2 diabetes mellitus—a protein
conformational disease characterized by the aggregation of islet amyloid polypeptide (IAPP) …
conformational disease characterized by the aggregation of islet amyloid polypeptide (IAPP) …
Cations as switches of amyloid-mediated membrane disruption mechanisms: calcium and IAPP
Disruption of the integrity of the plasma membrane by amyloidogenic proteins is linked to the
pathogenesis of a number of common age-related diseases. Although accumulating …
pathogenesis of a number of common age-related diseases. Although accumulating …
Amyloidogenic intrinsically disordered proteins: new insights into their self-assembly and their interaction with membranes
Aβ, IAPP, α-synuclein, and prion proteins belong to the amyloidogenic intrinsically
disordered proteins' family; indeed, they lack well defined secondary and tertiary structures …
disordered proteins' family; indeed, they lack well defined secondary and tertiary structures …
[HTML][HTML] Silybins inhibit human IAPP amyloid growth and toxicity through stereospecific interactions
S García-Viñuales, IM Ilie, AM Santoro… - … et Biophysica Acta (BBA …, 2022 - Elsevier
Type 2 Diabetes is a major public health threat, and its prevalence is increasing worldwide.
The abnormal accumulation of islet amyloid polypeptide (IAPP) in pancreatic β-cells is …
The abnormal accumulation of islet amyloid polypeptide (IAPP) in pancreatic β-cells is …
[HTML][HTML] Serum albumin impedes the amyloid aggregation and hemolysis of human islet amyloid polypeptide and alpha synuclein
Protein aggregation is a ubiquitous phenomenon underpinning the origins of a range of
human diseases. The amyloid aggregation of human islet amyloid polypeptide (IAPP) and …
human diseases. The amyloid aggregation of human islet amyloid polypeptide (IAPP) and …
Solvent induced amyloid polymorphism and the uncovering of the elusive class 3 amyloid topology
Z Dürvanger, F Bencs, DK Menyhárd… - Communications …, 2024 - nature.com
Abstract Aggregation-prone-motifs (APRs) of proteins are short segments, which–as isolated
peptides-form diverse amyloid-like crystals. We introduce two APRs-designed variants of the …
peptides-form diverse amyloid-like crystals. We introduce two APRs-designed variants of the …