Akkermansia muciniphila: paradigm for next-generation beneficial microorganisms

PD Cani, C Depommier, M Derrien, A Everard… - Nature Reviews …, 2022 - nature.com
Ever since Akkermansia muciniphila was discovered and characterized two decades ago,
numerous studies have shown that the lack or decreased abundance of this commensal …

Gut microbiota in overweight and obesity: crosstalk with adipose tissue

PD Cani, M Van Hul - Nature Reviews Gastroenterology & Hepatology, 2024 - nature.com
Overweight and obesity are characterized by excessive fat mass accumulation produced
when energy intake exceeds energy expenditure. One plausible way to control energy …

Gut microbiota Turicibacter strains differentially modify bile acids and host lipids

JB Lynch, EL Gonzalez, K Choy, KF Faull… - Nature …, 2023 - nature.com
Bacteria from the Turicibacter genus are prominent members of the mammalian gut
microbiota and correlate with alterations in dietary fat and body weight, but the specific …

[HTML][HTML] Fatty acid overproduction by gut commensal microbiota exacerbates obesity

T Takeuchi, K Kameyama, E Miyauchi, Y Nakanishi… - Cell metabolism, 2023 - cell.com
Although recent studies have highlighted the impact of gut microbes on the progression of
obesity and its comorbidities, it is not fully understood how these microbes promote these …

Metabolism and metabolic disorders and the microbiome: the intestinal microbiota associated with obesity, lipid metabolism, and metabolic health—pathophysiology …

J Aron-Wisnewsky, MV Warmbrunn, M Nieuwdorp… - Gastroenterology, 2021 - Elsevier
Changes in the intestinal microbiome have been associated with obesity and type 2
diabetes, in epidemiological studies and studies of the effects of fecal transfer in germ-free …

[HTML][HTML] Human gut microbiome: hopes, threats and promises

PD Cani - Gut, 2018 - gut.bmj.com
The microbiome has received increasing attention over the last 15 years. Although gut
microbes have been explored for several decades, investigations of the role of …

A high-fat diet increases gut microbiota biodiversity and energy expenditure due to nutrient difference

B Wang, Q Kong, X Li, J Zhao, H Zhang, W Chen… - Nutrients, 2020 - mdpi.com
A high-fat diet (HFD) can easily induce obesity and change the gut microbiota and its
metabolites. However, studies on the effects of high-fat diets on the host have drawn …

Next-Generation Beneficial Microbes: The Case of Akkermansia muciniphila

PD Cani, WM de Vos - Frontiers in microbiology, 2017 - frontiersin.org
Metabolic disorders associated with obesity and cardiometabolic disorders are worldwide
epidemic. Among the different environmental factors, the gut microbiota is now considered …

Gut bacteria from multiple sclerosis patients modulate human T cells and exacerbate symptoms in mouse models

E Cekanaviciute, BB Yoo, TF Runia… - Proceedings of the …, 2017 - pnas.org
The gut microbiota regulates T cell functions throughout the body. We hypothesized that
intestinal bacteria impact the pathogenesis of multiple sclerosis (MS), an autoimmune …

A purified membrane protein from Akkermansia muciniphila or the pasteurized bacterium improves metabolism in obese and diabetic mice

H Plovier, A Everard, C Druart, C Depommier… - Nature medicine, 2017 - nature.com
Obesity and type 2 diabetes are associated with low-grade inflammation and specific
changes in gut microbiota composition 1, 2, 3, 4, 5, 6, 7. We previously demonstrated that …