Protein design: From the aspect of water solubility and stability
Water solubility and structural stability are key merits for proteins defined by the primary
sequence and 3D-conformation. Their manipulation represents important aspects of the …
sequence and 3D-conformation. Their manipulation represents important aspects of the …
Protein phase separation: a new phase in cell biology
Cellular compartments and organelles organize biological matter. Most well-known
organelles are separated by a membrane boundary from their surrounding milieu. There are …
organelles are separated by a membrane boundary from their surrounding milieu. There are …
Structure of FUS protein fibrils and its relevance to self-assembly and phase separation of low-complexity domains
Polymerization and phase separation of proteins containing low-complexity (LC) domains
are important factors in gene expression, mRNA processing and trafficking, and localization …
are important factors in gene expression, mRNA processing and trafficking, and localization …
A guide to studying protein aggregation
Disrupted protein folding or decreased protein stability can lead to the accumulation of
(partially) un‐or misfolded proteins, which ultimately cause the formation of protein …
(partially) un‐or misfolded proteins, which ultimately cause the formation of protein …
Neurotoxic amyloidogenic peptides in the proteome of SARS-COV2: potential implications for neurological symptoms in COVID-19
COVID-19 is primarily known as a respiratory disease caused by SARS-CoV-2. However,
neurological symptoms such as memory loss, sensory confusion, severe headaches, and …
neurological symptoms such as memory loss, sensory confusion, severe headaches, and …
Mechanistic view of hnRNPA2 low-complexity domain structure, interactions, and phase separation altered by mutation and arginine methylation
Summary hnRNPA2, a component of RNA-processing membraneless organelles, forms
inclusions when mutated in a syndrome characterized by the degeneration of neurons …
inclusions when mutated in a syndrome characterized by the degeneration of neurons …
Factors affecting the physical stability (aggregation) of peptide therapeutics
KL Zapadka, FJ Becher… - Interface …, 2017 - royalsocietypublishing.org
The number of biological therapeutic agents in the clinic and development pipeline has
increased dramatically over the last decade and the number will undoubtedly continue to …
increased dramatically over the last decade and the number will undoubtedly continue to …
Structure and aggregation mechanisms in amyloids
The aggregation of a polypeptide chain into amyloid fibrils and their accumulation and
deposition into insoluble plaques and intracellular inclusions is the hallmark of several …
deposition into insoluble plaques and intracellular inclusions is the hallmark of several …
Biophysical processes underlying cross-seeding in amyloid aggregation and implications in amyloid pathology
Abnormal aggregation of proteins into filamentous aggregates commonly associates with
many diseases, such as Alzheimer's disease, Parkinson's disease and type-2 diabetes …
many diseases, such as Alzheimer's disease, Parkinson's disease and type-2 diabetes …
A short motif in the N-terminal region of α-synuclein is critical for both aggregation and function
CPA Doherty, SM Ulamec, R Maya-Martinez… - Nature structural & …, 2020 - nature.com
Aggregation of human α-synuclein (αSyn) is linked to Parkinson's disease (PD) pathology.
The central region of the αSyn sequence contains the non-amyloid β-component (NAC) …
The central region of the αSyn sequence contains the non-amyloid β-component (NAC) …