Nucleation of new peptide and protein aggregates on the surfaces of amyloid fibrils of the
same peptide or protein has emerged in the past two decades as a major pathway for both …

The presence of phosphorus (P) in discharged wastewater can lead to water pollution
events and eutrophication. Given the increasing consumption of phosphate (PO 4 3−) rocks …

This scientific paper presents an overview of continuous solution crystallization in the
pharmaceutical industry. Since the specific knowledge spectrum of precipitation is very …

Continuous crystallization has gained interest in the pharmaceutical sector as part of the
drive toward the transition from exclusive batch manufacturing to integrated continuous …

Secondary nucleation can bring the crystallization process into a more easily controlled
state, and it is playing an important role in controlling crystal size distribution, polymorphism …

Hot melt extrusion (HME) can be used to produce amorphous solid dispersions (ASDs) at
temperatures below the drug's melting point if the drug and polymer exhibit melting point …

Despite their widespread use for purification, our current methods for the development of
solution crystallization processes lack a sufficient understanding on how impurities …

In pharmaceuticals manufacturing, the conversion of conventional batch crystallisations to
continuous mode has the potential for intensified, compact operation and more consistent …

The solubility advantage of amorphous solid dispersions (ASDs) is contingent upon
supersaturation being generated and maintained. If crystals are present within an ASD …

Process alternatives for continuous crystallization, ie, cascades of mixed suspension, mixed
product removal crystallizers (MSMPRCs) and plug flow crystallizers (PFCs), as well as …