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Hypertranscription: the invisible hand in stem cell biology
Stem cells are the fundamental drivers of growth during development and adult organ
homeostasis. The properties that define stem cells–self-renewal and differentiation–are …
homeostasis. The properties that define stem cells–self-renewal and differentiation–are …
[HTML][HTML] Boosting BDNF in muscle rescues impaired axonal transport in a mouse model of DI-CMTC peripheral neuropathy
ER Rhymes, RL Simkin, J Qu, D Villarroel-Campos… - Neurobiology of …, 2024 - Elsevier
Abstract Charcot-Marie-Tooth disease (CMT) is a genetic peripheral neuropathy caused by
mutations in many functionally diverse genes. The aminoacyl-tRNA synthetase (ARS) …
mutations in many functionally diverse genes. The aminoacyl-tRNA synthetase (ARS) …
The node of Ranvier influences the in vivo axonal transport of mitochondria and signaling endosomes
AP Tosolini, F Abatecola, S Negro, JN Sleigh… - Iscience, 2024 - cell.com
Efficient long-range axonal transport is essential for maintaining neuronal function, and
perturbations in this process underlie severe neurological diseases. Nodes of Ranvier …
perturbations in this process underlie severe neurological diseases. Nodes of Ranvier …
Processivity and BDNF-dependent modulation of signalling endosome axonal transport are impaired in aged mice
D Villarroel-Campos, ER Rhymes, AP Tosolini, B Malik… - bioRxiv, 2025 - biorxiv.org
A healthy nervous system is reliant upon an efficient transport network to deliver essential
cargoes throughout the extensive and polarised architecture of neurons. The trafficking of …
cargoes throughout the extensive and polarised architecture of neurons. The trafficking of …