Snakebite: When the human touch becomes a bad touch

BG Fry - Toxins, 2018 - mdpi.com
Many issues and complications in treating snakebite are a result of poor human social,
economic and clinical intervention and management. As such, there is scope for significant …

Inflammatory progression in patients undergoing extracorporeal membrane oxygenation

Y Yao, H Kang, Y Cheng, X Su… - Current Molecular …, 2024 - benthamdirect.com
Extracorporeal membrane oxygenation (ECMO) is identified as a novel therapeutic strategy
that offers short-term support to the metabolism of the heart and lungs in humans. Recently …

Dynamic genetic differentiation drives the widespread structural and functional convergent evolution of snake venom proteinaceous toxins

B **e, D Dashevsky, D Rokyta, P Ghezellou, B Fathinia… - BMC biology, 2022 - Springer
Background The explosive radiation and diversification of the advanced snakes (superfamily
Colubroidea) was associated with changes in all aspects of the shared venom system …

Coagulotoxicity of Bothrops (Lancehead Pit-Vipers) Venoms from Brazil: Differential Biochemistry and Antivenom Efficacy Resulting from Prey-Driven Venom …

LF Sousa, CN Zdenek, JS Dobson, B Op den Brouw… - Toxins, 2018 - mdpi.com
Lancehead pit-vipers (Bothrops genus) are an extremely diverse and medically important
group responsible for the greatest number of snakebite envenomations and deaths in South …

Resistance Is not futile: widespread convergent evolution of resistance to alpha-neurotoxic snake venoms in caecilians (Amphibia: Gymnophiona)

M Mancuso, S Zaman, ST Maddock, RG Kamei… - International Journal of …, 2023 - mdpi.com
Predatory innovations impose reciprocal selection pressures upon prey. The evolution of
snake venom alpha-neurotoxins has triggered the corresponding evolution of resistance in …

[HTML][HTML] From venom to vein: Factor VII activation as a major pathophysiological target for procoagulant Australian elapid snake venoms

U Chandrasekara, A Chowdhury, L Seneci… - Toxins, 2024 - pmc.ncbi.nlm.nih.gov
Australian elapid snake venoms are uniquely procoagulant, utilizing blood clotting enzyme
Factor Xa (FXa) as a toxin, which evolved as a basal trait in this clade. The subsequent …

[HTML][HTML] The Contrasting Effects of Bothrops lanceolatus and Bothrops atrox Venom on Procoagulant Activity and Thrombus Stability under Blood Flow Conditions

F Radouani, P Jalta, C Rapon, C Lezin, C Branford… - Toxins, 2024 - mdpi.com
Background: Consumption coagulopathy and hemorrhagic syndrome are the typical
features of Bothrops sp. snake envenoming. In contrast, B. lanceolatus envenoming can …

Electrostatic resistance to alpha-neurotoxins conferred by charge reversal mutations in nicotinic acetylcholine receptors

RJ Harris, BG Fry - Proceedings of the Royal Society B, 2021 - royalsocietypublishing.org
The evolution of venom resistance through coevolutionary chemical arms races has arisen
multiple times throughout animalia. Prior documentation of resistance to snake venom α …

Venom-induced blood disturbances by palearctic viperid snakes, and their relative neutralization by antivenoms and enzyme-inhibitors

A Chowdhury, CN Zdenek, MR Lewin, R Carter… - Frontiers in …, 2021 - frontiersin.org
Palearctic vipers are medically significant snakes in the genera Daboia, Macrovipera,
Montivipera, and Vipera which occur throughout Europe, Central Asia, Near and Middle …

A clot twist: extreme variation in coagulotoxicity mechanisms in Mexican neotropical rattlesnake venoms

L Seneci, CN Zdenek, A Chowdhury… - Frontiers in …, 2021 - frontiersin.org
Rattlesnakes are a diverse clade of pit vipers (snake family Viperidae, subfamily Crotalinae)
that consists of numerous medically significant species. We used validated in vitro assays …