Roles of JAK2 in aging, inflammation, hematopoiesis and malignant transformation
Clonal alterations in hematopoietic cells occur during aging and are often associated with
the establishment of a subclinical inflammatory environment. Several age-related conditions …
the establishment of a subclinical inflammatory environment. Several age-related conditions …
Age-related macular degeneration: A two-level model hypothesis
Age-related diseases, including age-related macular degeneration (AMD), are of growing
importance in a world where population ageing has become a dominant global trend …
importance in a world where population ageing has become a dominant global trend …
Prevalence and phenotypes of JAK2 V617F and calreticulin mutations in a Danish general population
S Cordua, L Kjaer, V Skov, N Pallisgaard… - Blood, The Journal …, 2019 - ashpublications.org
Abstract The JAK2 V617F and calreticulin mutations (CALR) are frequent within
myeloproliferative neoplasms (MPNs). JAK2 V617F has been detected in the general …
myeloproliferative neoplasms (MPNs). JAK2 V617F has been detected in the general …
[HTML][HTML] Understanding the impact of feedback regulations on blood cell production and leukemia dynamics using model analysis and simulation of clinically relevant …
Acute myeloid leukemia (AML) is a paradigmatic example of a stem cell-driven cancer. AML
belongs to the most aggressive malignancies and has a poor prognosis. A hallmark of AML …
belongs to the most aggressive malignancies and has a poor prognosis. A hallmark of AML …
The critical role of inflammation in the pathogenesis and progression of myeloid malignancies
Hematopoietic stem cells (HSCs) maintain an organism's immune system for a lifetime, and
derangements in HSC proliferation and differentiation result in hematologic malignancies …
derangements in HSC proliferation and differentiation result in hematologic malignancies …
Inherited polygenic effects on common hematological traits influence clonal selection on JAK2V617F and the development of myeloproliferative neoplasms
Myeloproliferative neoplasms (MPNs) are chronic cancers characterized by overproduction
of mature blood cells. Their causative somatic mutations, for example, JAK2 V617F, are …
of mature blood cells. Their causative somatic mutations, for example, JAK2 V617F, are …
Perspectives on interferon-alpha in the treatment of polycythemia vera and related myeloproliferative neoplasms: minimal residual disease and cure?
HC Hasselbalch, MO Holmström - Seminars in Immunopathology, 2019 - Springer
The first clinical trials of the safety and efficacy of interferon-alpha2 (IFN-alpha2) were
performed about 30 years ago. Since then, several single-arm studies have convincingly …
performed about 30 years ago. Since then, several single-arm studies have convincingly …
Mutations, inflammation and phenotype of myeloproliferative neoplasms
S Hermouet - Frontiers in Oncology, 2023 - frontiersin.org
Knowledge on the myeloproliferative neoplasms (MPNs)–polycythemia vera (PV), essential
thrombocythemia (ET), primary myelofibrosis (PMF)–has accumulated since the discovery of …
thrombocythemia (ET), primary myelofibrosis (PMF)–has accumulated since the discovery of …
HSC niche dynamics in regeneration, pre-malignancy, and cancer: insights from mathematical modeling
The hematopoietic stem cell (HSC) niche is a crucial driver of regeneration and malignancy.
Its interaction with hematopoietic and malignant stem cells is highly complex and direct …
Its interaction with hematopoietic and malignant stem cells is highly complex and direct …
Inflammatory microenvironment and specific T cells in myeloproliferative neoplasms: immunopathogenesis and novel immunotherapies
V Nasillo, G Riva, A Paolini, F Forghieri… - International Journal of …, 2021 - mdpi.com
The Philadelphia-negative myeloproliferative neoplasms (MPNs) are malignancies of the
hematopoietic stem cell (HSC) arising as a consequence of clonal proliferation driven by …
hematopoietic stem cell (HSC) arising as a consequence of clonal proliferation driven by …