The purpose of the lens is to project a sharply focused, undistorted image of the visual
surround onto the neural retina. The first pre-requisite, therefore, is that the tissue should be …

Ocular lens development represents an advantageous system in which to study regulatory
mechanisms governing cell fate decisions, extracellular signaling, cell and tissue …

Purpose To assess the utility of integrating genomic data from next-generation sequencing
and phenotypic data to enhance the diagnosis of bilateral congenital cataract (CC). Design …

Background Aquaporin (AQP) water channels are best known as passive transporters of
water that are vital for water homeostasis. Scope of review AQP knockout studies in whole …

The factors that regulate the size of organs to ensure that they fit within an organism are not
well understood. A simple organ, the ocular lens serves as a useful model with which to …

Background All thirteen known mammalian aquaporins have been detected in the eye.
Moreover, aquaporins have been identified as playing essential roles in ocular functions …

Cataract and presbyopia are the leading cause of vision loss and impaired vision,
respectively, worldwide. Changes in lens biochemistry and physiology with age are …

Cataracts are the principal cause of treatable blindness worldwide. Inherited congenital
cataract (CC) shows all types of inheritance patterns in a syndromic and nonsyndromic form …

The lens is a multicellular, but avascular tissue that must stay transparent to allow normal
transmission of light and focusing of it on the retina. Damage to lens cells and/or proteins …

Mercury, one of the most toxic elements, exists in various chemical forms each with different
toxicities and health implications. Some methylated mercury forms, one of which exists in …