The stimulator of interferon genes (STING) cellular signaling pathway is a promising target
for cancer immunotherapy. Activation of the intracellular STING protein triggers the …

Until recently, the development of new human adjuvants was held back by a poor
understanding of their mechanisms of action. The field was revolutionized by the discovery …

One of the most significant conceptual advances in immunology in recent history is the
recognition that signals from the innate immune system are required for induction of …

Malaria is caused by Plasmodium species transmitted by Anopheles mosquitoes. Following
a mosquito bite, Plasmodium sporozoites migrate from skin to liver, where extensive …

The presentation of exogenous antigens on MHC class I molecules, known as cross-
presentation, is essential for the initiation of CD8+ T cell responses. In vivo, cross …

Dendritic cells are at the center of immune responses. They are defined by their ability to
sense the environment, take up and process antigen, migrate to secondary lymphoid …

Although in vitro observations suggest that cross-presentation of antigens is mediated
primarily by CD8α+ dendritic cells, in vivo analysis has been hampered by the lack of …

As a population, dendritic cells (DC s) appear to be the best cross‐presenters of internalized
antigens on major histocompatibility complex class I molecules in the mouse. To do this, DC …

The AP1 transcription factor Batf3 is required for homeostatic development of CD8α+
classical dendritic cells that prime CD8 T-cell responses against intracellular pathogens …

Malaria, caused by infection with Plasmodium parasites, drives multiple regulatory
responses across the immune landscape. These regulatory responses help to protect …