Myeloid-derived suppressor cells (MDSCs) are a heterogenic population of immature
myeloid cells with immunosuppressive effects, which undergo massive expansion during …

The clinical responses observed following treatment with immune checkpoint inhibitors
(ICIs) support immunotherapy as a potential anticancer treatment. However, a large …

The innate immune system has the capacity to detect 'non-self'molecules derived from
pathogens, known as pathogen-associated molecular patterns, via pattern recognition …

Myeloid-derived suppressor cells (MDSCs) have emerged as major regulators of immune
responses in cancer and other pathological conditions. In recent years, ample evidence …

Abstract Anti-PD-1/PD-L1 agents have transformed the treatment landscape of advanced
non-small cell lung cancer (NSCLC). To expand our understanding of the molecular features …

Myeloid-derived suppressor cells (MDSC) are one of the major components of the tumor
microenvironment. The main feature of these cells is their potent immune suppressive …

Myeloid cells are the most abundant nucleated haematopoietic cells in the human body and
are a collection of distinct cell populations with many diverse functions. The three groups of …

Myeloid-derived suppressor cells (MDSCs) are a heterogeneous population of cells that
expand during cancer, inflammation and infection, and that have a remarkable ability to …

Under steady-state conditions, bone marrow-derived immature myeloid cells (IMC)
differentiate into granulocytes, macrophages and dendritic cells (DCs). This differentiation is …

The tumor microenvironment (TME) is an integral part of cancer. Recognition of the essential
nature of the TME in cancer evolution has led to a shift from a tumor cell-centered view of …