Members of the 'Bacillus subtilis group'include some of the most commercially important
bacteria, used for the production of a wide range of industrial enzymes and fine …

Recent work has shed light on the abundance and diversity of d-amino acids in bacterial
extracellular/periplasmic molecules, bacterial cell culture, and bacteria-rich environments …

Many clinically used drugs are derived from or inspired by bacterial natural products that
often are produced through nonribosomal peptide synthetases (NRPSs), megasynthetases …

Non-ribosomal peptide synthetases (NRPSs) are giant enzyme machines that activate
amino acids in an assembly line fashion. As NRPSs are not restricted to the incorporation of …

Peptide natural products show broad biological properties and are commonly produced by
orthogonal ribosomal and nonribosomal pathways in prokaryotes and eukaryotes. To …

Natural or synthetic cyclic peptides often possess pronounced bioactivity. Their mass
spectrometric characterization is difficult due to the predominant occurrence of non …

Marine environments are largely unexplored and can be a source of new molecules for the
treatment of many diseases such as malaria, cancer, tuberculosis, HIV etc. The Marine …

Highlights•Novel approaches are needed to tackle undruggable targets.•Larger macrocycles
are an underexplored region of drug space.•mRNA-display has been adapted for the …

Norine, the unique resource dedicated to nonribosomal peptides (NRPs), is now updated
with a new pipeline to automate massive sourcing and enhance annotation. External …

Abstract Non-Ribosomal Peptides (NRPs) represent a biomedically important class of
natural products that include a multitude of antibiotics and other clinically used drugs. NRPs …