During adaptive immunity, B cells differentiate either into memory B cells or plasma cells and
produce antibodies against foreign antigens to fight infection. Additionally, they behave as …

Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by multiple
organ inflammatory damage and wide spectrum of autoantibodies. The autoantibodies …

In addition to serum immunoglobulins, memory B cell (MBC) generation against severe
acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is another layer of immune …

How infection by a viral variant showing antigenic drift impacts a preformed mature human
memory B cell (MBC) repertoire remains an open question. Here, we studied the MBC …

Summary The SARS-CoV-2 Omicron variant can escape neutralization by vaccine-elicited
and convalescent antibodies. Memory B cells (MBCs) represent another layer of protection …

Memory B cells (MBCs) can persist for a lifetime, but the mechanisms that allow their long-
term survival remain poorly understood. Here, we isolated and analyzed human splenic …

Autoimmune diseases with B cell–directed therapeutics approved by the US Food and Drug
Administration are surprisingly diverse in clinical manifestations and pathophysiology. In this …

Personalized cancer vaccines based on resected tumors from patients is promising to
address tumor heterogeneity to inhibit tumor recurrence or metastasis. However, it remains …

The efficacy of the B cell-targeting drug rituximab (RTX) in childhood idiopathic nephrotic
syndrome (INS) suggests that B cells may be implicated in disease pathogenesis. However …

Myasthenia gravis (MG) is an autoantibody-mediated autoimmune disorder of the
neuromuscular junction. A small subset of patients (< 10%) with MG, have autoantibodies …