The Hippo pathway: biology and pathophysiology
The Hippo pathway was initially discovered in Drosophila melanogaster as a key regulator
of tissue growth. It is an evolutionarily conserved signaling cascade regulating numerous …
of tissue growth. It is an evolutionarily conserved signaling cascade regulating numerous …
Cardiomyocyte maturation: new phase in development
Y Guo, WT Pu - Circulation research, 2020 - Am Heart Assoc
Maturation is the last phase of heart development that prepares the organ for strong,
efficient, and persistent pum** throughout the mammal's lifespan. This process is …
efficient, and persistent pum** throughout the mammal's lifespan. This process is …
[HTML][HTML] Deciphering osteoarthritis genetics across 826,690 individuals from 9 populations
CG Boer, K Hatzikotoulas, L Southam, L Stefánsdóttir… - Cell, 2021 - cell.com
Osteoarthritis affects over 300 million people worldwide. Here, we conduct a genome-wide
association study meta-analysis across 826,690 individuals (177,517 with osteoarthritis) and …
association study meta-analysis across 826,690 individuals (177,517 with osteoarthritis) and …
The Hippo pathway in the heart: pivotal roles in development, disease, and regeneration
Abstract The Hippo–YAP (Yes-associated protein) pathway is an evolutionarily and
functionally conserved regulator of organ size and growth with crucial roles in cell …
functionally conserved regulator of organ size and growth with crucial roles in cell …
[HTML][HTML] Notoginsenoside R1-loaded mesoporous silica nanoparticles targeting the site of injury through inflammatory cells improves heart repair after myocardial …
H Li, J Zhu, Y Xu, F Mou, X Shan, Q Wang, B Liu… - Redox Biology, 2022 - Elsevier
Abstract Notoginsenoside R1 (NGR1) is the main monomeric component extracted from the
dried roots and rhizomes of Panax notoginseng, and exerts pharmacological action against …
dried roots and rhizomes of Panax notoginseng, and exerts pharmacological action against …
Cardiac fibroblasts and mechanosensation in heart development, health and disease
The term 'mechanosensation'describes the capacity of cells to translate mechanical stimuli
into the coordinated regulation of intracellular signals, cellular function, gene expression …
into the coordinated regulation of intracellular signals, cellular function, gene expression …
Role of YAP/TAZ in cell lineage fate determination and related signaling pathways
BC Heng, X Zhang, D Aubel, Y Bai, X Li… - Frontiers in cell and …, 2020 - frontiersin.org
The penultimate effectors of the Hippo signaling pathways YAP and TAZ, are transcriptional
co-activator proteins that play key roles in many diverse biological processes, ranging from …
co-activator proteins that play key roles in many diverse biological processes, ranging from …
An overview of signaling pathways regulating YAP/TAZ activity
BC Heng, X Zhang, D Aubel, Y Bai, X Li, Y Wei… - Cellular and Molecular …, 2021 - Springer
YAP and TAZ are ubiquitously expressed homologous proteins originally identified as
penultimate effectors of the Hippo signaling pathway, which plays a key role in maintaining …
penultimate effectors of the Hippo signaling pathway, which plays a key role in maintaining …
Hippo pathway dysregulation in gastric cancer: from Helicobacter pylori infection to tumor promotion and progression
The Hippo pathway plays a critical role for balancing proliferation and differentiation, thus
regulating tissue homeostasis. The pathway acts through a kinase cascade whose final …
regulating tissue homeostasis. The pathway acts through a kinase cascade whose final …
Metabolites regulate cell signaling and growth via covalent modification of proteins
Metabolites affect cell growth in two different ways. First, they serve as building blocks for
biomass accumulation. Second, metabolites regulate the activity of growth-relevant …
biomass accumulation. Second, metabolites regulate the activity of growth-relevant …