Ferroptosis turns 10: Emerging mechanisms, physiological functions, and therapeutic applications

BR Stockwell - Cell, 2022 - cell.com
Ferroptosis, a form of cell death driven by iron-dependent lipid peroxidation, was identified
as a distinct phenomenon and named a decade ago. Ferroptosis has been implicated in a …

Ferroptosis: molecular mechanisms and health implications

D Tang, X Chen, R Kang, G Kroemer - Cell research, 2021 - nature.com
Cell death can be executed through different subroutines. Since the description of
ferroptosis as an iron-dependent form of non-apoptotic cell death in 2012, there has been …

Ferroptosis: past, present and future

J Li, F Cao, H Yin, Z Huang, Z Lin, N Mao, B Sun… - Cell death & …, 2020 - nature.com
Ferroptosis is a new type of cell death that was discovered in recent years and is usually
accompanied by a large amount of iron accumulation and lipid peroxidation during the cell …

Ferroptosis: machinery and regulation

X Chen, J Li, R Kang, DJ Klionsky, D Tang - Autophagy, 2021 - Taylor & Francis
Ferroptosis is an iron-dependent, non-apoptotic form of regulated cell death caused by lipid
peroxidation, which is controlled by integrated oxidation and antioxidant systems. The iron …

Ferroptosis: mechanisms and links with diseases

H Yan, T Zou, Q Tuo, S Xu, H Li, AA Belaidi… - Signal transduction and …, 2021 - nature.com
Ferroptosis is an iron-dependent cell death, which is different from apoptosis, necrosis,
autophagy, and other forms of cell death. The process of ferroptotic cell death is defined by …

Ferroptosis, necroptosis, and pyroptosis in anticancer immunity

R Tang, J Xu, B Zhang, J Liu, C Liang, J Hua… - Journal of hematology & …, 2020 - Springer
In recent years, cancer immunotherapy based on immune checkpoint inhibitors (ICIs) has
achieved considerable success in the clinic. However, ICIs are significantly limited by the …

Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018

L Galluzzi, I Vitale, SA Aaronson, JM Abrams… - Cell Death & …, 2018 - nature.com
Over the past decade, the Nomenclature Committee on Cell Death (NCCD) has formulated
guidelines for the definition and interpretation of cell death from morphological, biochemical …

[HTML][HTML] Ferroptosis: a regulated cell death nexus linking metabolism, redox biology, and disease

BR Stockwell, JPF Angeli, H Bayir, AI Bush, M Conrad… - Cell, 2017 - cell.com
Ferroptosis is a form of regulated cell death characterized by the iron-dependent
accumulation of lipid hydroperoxides to lethal levels. Emerging evidence suggests that …

Molecular mechanisms of cell death in neurological diseases

D Moujalled, A Strasser, JR Liddell - Cell Death & Differentiation, 2021 - nature.com
Tightly orchestrated programmed cell death (PCD) signalling events occur during normal
neuronal development in a spatially and temporally restricted manner to establish the neural …

The therapeutic potential of targeting regulated non-apoptotic cell death

K Hadian, BR Stockwell - Nature Reviews Drug Discovery, 2023 - nature.com
Cell death is critical for the development and homeostasis of almost all multicellular
organisms. Moreover, its dysregulation leads to diverse disease states. Historically …