Abstract Cisplatin or (SP-4-2)-diamminedichloridoplatinum (II) is one of the most potential
and widely used drugs for the treatment of various solid cancers such as testicular, ovarian …

Salvia miltiorrhiza:(Danshen) is a significant (traditional Chinese medication) natural
remedy, enhancing blood circulation and clear blood stasis. In this view, it is widely used …

Therapy resistance is a characteristic of cancer cells that significantly reduces the
effectiveness of drugs. Despite the popularity of cisplatin (CP) as a chemotherapeutic agent …

Despite significant progressions in treatment modalities over the last decade, either cancer
incidence or mortality is continuously on the rise throughout the world. Current anticancer …

Hepatocellular carcinoma (HCC) is the most common primary liver tumor and is often
diagnosed at an unresectable advanced stage. Systemic chemotherapy as well as …

There is a need for new, safer, and more effective agents to treat cancer. Cytostatics that
have transition metals at their core have attracted renewed interest from scientists …

How to address the resistance of cisplatin (CDDP) has always been a clinical challenge.
The resistance mechanism of platinum-based drugs is very complex, including nuclear DNA …

Rapid proliferation is a hallmark of cancer associated with sensitivity to therapeutics that
cause DNA replication stress (RS). Many tumors exhibit drug resistance, however, via …

Cisplatin-based chemotherapeutic regimens are the most frequently used adjuvant
treatments for many types of cancer. However, the development of chemoresistance to …

Cancer therapy is aimed at the elimination of tumor cells and acts via the cessation of cell
proliferation and induction of cell death. Many research publications discussing the …