Genetics of clubfoot; recent progress and future perspectives

S Basit, KI Khoshhal - European Journal of Medical Genetics, 2018 - Elsevier
Clubfoot or talipes equinovarus (TEV) is an inborn three-dimensional deformity of leg, ankle
and foot. It results from structural defects of several tissues of foot and lower leg leading to …

The genetic epidemiology of joint shape and the development of osteoarthritis

JM Wilkinson, E Zeggini - Calcified tissue international, 2021 - Springer
Congruent, low-friction relative movement between the articulating elements of a synovial
joint is an essential pre-requisite for sustained, efficient, function. Where disorders of joint …

Developmental dysplasia of hip: perspectives in genetic screening

R Zamborsky, M Kokavec, S Harsanyi, D Attia… - Medical …, 2019 - mdpi.com
Development dysplasia of the hip (DDH) is a complex developmental disorder despite being
a relatively common condition mainly caused by incompatibility of the femoral head and the …

[HTML][HTML] Mining prognostic significance of MEG3 in human breast cancer using bioinformatics analysis

X Cui, Q Yi, X **g, Y Huang, J Tian, C Long… - Cellular Physiology and …, 2018 - karger.com
Background/Aims: Maternally expressed gene 3 (MEG3) is an imprinted gene with maternal
expression, which may function as a tumor suppressor by inhibiting angiogenesis. To …

Genetics of developmental dysplasia of the hip

S Harsanyi, R Zamborsky, M Kokavec… - European journal of …, 2020 - Elsevier
In the last decade, the advances in the molecular analyses and sequencing techniques
allowed researchers to study developmental dysplasia of the hip (DDH) more thoroughly …

Current knowledge on the genetic background of developmental dysplasia of the hip and the histomorphological status of the cartilage

I Bohaček, M Plečko, T Duvančić… - Croatian medical …, 2020 - pmc.ncbi.nlm.nih.gov
Developmental dysplasia of the hip (DDH) represents a morphological abnormality
characterized by the incongruity of femoral head and acetabulum. It ranges from mild …

Genetic predisposition to developmental dysplasia of the hip

E Kenanidis, NK Gkekas, A Karasmani… - The Journal of …, 2020 - Elsevier
Background The etiopathogenesis of developmental dysplasia of the hip (DDH) has not
been clarified. This systematic review evaluated current literature concerning all known …

Molecular mechanisms and genetic factors contributing to the developmental dysplasia of the hip

X Zhao, S Liu, Z Yang, Y Li - Frontiers in Genetics, 2024 - frontiersin.org
The most prevalent hip disease in neonates is developmental dysplasia of the hip (DDH). A
timely and accurate diagnosis is required to provide the most effective treatment for pediatric …

Developmental dysplasia of the hip: a systematic review of susceptibility genes and epigenetics

J Wen, H **, X Kong, W Chai - Gene, 2023 - Elsevier
Background Developmental dysplasia of the hip (DDH) is a complex developmental
deformity whose pathogenesis and susceptibility-related genes have yet to be elucidated …

Whole exome sequencing of 28 families of Danish descent reveals novel candidate genes and pathways in developmental dysplasia of the hip

M Dembic, L van Brakel Andersen, MJ Larsen… - Molecular Genetics and …, 2023 - Springer
Developmental dysplasia of the hip (DDH) is a common condition involving instability of the
hip with multifactorial etiology. Early diagnosis and treatment are critical as undetected DDH …