Since Hedin's characterization of trypsin and antitrypsin in 1906,(1) arguably the first
account of a regulatory protein–protein interaction (PPI), contemporary understanding of …

Guanine nucleotide–binding proteins regulate a variety of processes, including sensual
perception, protein synthesis, various transport processes, and cell growth and …

Understanding protein–protein interactions (PPIs) is quite important to elucidate crucial
biological processes and even design compounds that interfere with PPIs with …

Surface proteins of Gram-positive bacteria are linked to the bacterial cell wall by a
mechanism that involves cleavage of a conserved Leu-Pro-X-Thr-Gly (LPXTG) motif and that …

This review focuses on one family of the known cAMP receptors, the exchange proteins
directly activated by cAMP (EPACs), also known as the cAMP-regulated guanine nucleotide …

The biological olfactory system is the sensory system responsible for the detection of the
chemical composition of the environment. Several attempts to mimic biological olfactory …

A long-held tenet in inositol-lipid signaling is that cleavage of membrane phosphoinositides
by phospholipase Cβ (PLCβ) isozymes to increase cytosolic Ca2+ in living cells is exclusive …

Signal transduction with the diatomic radical nitric oxide (NO) is involved in a number of
important physiological processes, including smooth muscle relaxation and …

Nitric oxide (NO) is an essential signaling molecule in biological systems. In mammals, the
diatomic gas is critical to the cyclic guanosine monophosphate (cGMP) pathway as it …

The D1-like (D1, D5) and D2-like (D2, D3, D4) classes of dopamine receptors each has
shared signaling properties that contribute to the definition of the receptor class, although …