ABL-family proteins comprise one of the best conserved branches of the tyrosine kinases.
Each ABL protein contains an SH3-SH2-TK (Src homology 3–Src homology 2–tyrosine …

Abstract Src homology 3 (SH3) domains are involved in the regulation of important cellular
pathways, such as cell proliferation, migration and cytoskeletal modifications. Recognition of …

Abstract The Crk adaptor proteins (Crk and CrkL) constitute an integral part of a network of
essential signal transduction pathways in humans and other organisms that act as major …

The Abl-family non-receptor tyrosine kinases are essential regulators of the cytoskeleton.
They transduce diverse extracellular cues into cytoskeletal rearrangements that have …

Autoinhibition is being widely used in nature to repress otherwise constitutive protein
activities and is typically regulated by extrinsic factors. Here we show that autoinhibition can …

Abstract Type 3 Secretion System (T3SS) is a highly conserved virulence structure that plays
an essential role in the pathogenesis of many Gram-negative pathogenic bacteria, including …

Proline switches, controlled by cis-trans isomerization, have emerged as a particularly
effective regulatory mechanism in a wide range of biological processes. Here we report the …

The Crk adaptor protein, which is encoded by two splice variants termed CrkI and CrkII,
contains both SH2 and SH3 domains but no catalytic region. It is thought to function in signal …

The Crk family of adaptor proteins (CrkI, CrkII, and CrkL), originally discovered as the
oncogene fusion product, v-Crk, of the CT10 chicken retrovirus, lacks catalytic activity but …

Adaptor proteins are named for their function in assembling complexes of cellular proteins to
execute and facilitate transmission of signals. The Crk family of adaptors consists of 2 …