Host sphingolipids: Perspective immune adjuvant for controlling SARS-CoV-2 infection for managing COVID-19 disease
Sphingolipids are potent bioactive agents involved in the pathogenesis of various
respiratory bacterial infections. To date, several sphingolipid derivatives are known, but S1P …
respiratory bacterial infections. To date, several sphingolipid derivatives are known, but S1P …
FTY720 ameliorates MOG‐induced experimental autoimmune encephalomyelitis by suppressing both cellular and humoral immune responses
Abstract FTY720, an oral sphingosine 1‐phosphate (S1P) receptor modulator, has shown
efficacy in phase II trials in patients with relapsing‐remitting multiple sclerosis (MS) …
efficacy in phase II trials in patients with relapsing‐remitting multiple sclerosis (MS) …
Ascomycete derivative to MS therapeutic: S1P receptor modulator FTY720
PC Hiestand, M Rausch, DP Meier… - Natural Compounds as …, 2008 - Springer
Fingolimod (FTY720) represents the first in a new class of immune-modulators whose target
is sphingosine-1-phosphate (S1P) receptors. It was first identified by researchers at Kyoto …
is sphingosine-1-phosphate (S1P) receptors. It was first identified by researchers at Kyoto …
Tempering macrophage plasticity for controlling SARS-CoV-2 infection for managing COVID-19 disease
D Toor, A Jain, S Kalhan, H Manocha… - Frontiers in …, 2020 - frontiersin.org
Background The recent outbreak of the COVID-19 has posed an unprecedented challenge
to the health care system. Effective and immediate therapeutics are urgently required to …
to the health care system. Effective and immediate therapeutics are urgently required to …
A new lipophilic amino alcohol, chemically similar to compound FTY720, attenuates the pathogenesis of experimental autoimmune encephalomyelitis by PI3K/Akt …
LC da Silva, IV de Assis Lima, MCM da Silva… - International …, 2020 - Elsevier
Experimental autoimmune encephalomyelitis (EAE) is one of the main animal models used
for the study of Multiple Sclerosis (MS). Long-chain lipophilic amino alcohols with …
for the study of Multiple Sclerosis (MS). Long-chain lipophilic amino alcohols with …
The influence of sphingosine-1-phosphate receptor signaling on lymphocyte trafficking: how a bioactive lipid mediator grew up from an “immature” vascular maturation …
Since the initial observations that highlighted the importance of lymphocyte trafficking for
immune responses, the pathways utilized by B and T lymphocytes to recirculate and …
immune responses, the pathways utilized by B and T lymphocytes to recirculate and …
Tacrolimus in combination with FTY720—an analysis of renal and blood parameters
AP Gallo, LBL Silva, M Franco, EA Burdmann… - International …, 2006 - Elsevier
Calcineurin inhibitors (CNIs) are routinely used in immunosuppressive therapy and both
Cyclosporine (CsA) and Tacrolimus (FK506) show similar efficacies to prevent rejection and …
Cyclosporine (CsA) and Tacrolimus (FK506) show similar efficacies to prevent rejection and …
The thymus is required for the ability of FTY720 to prolong skin allograft survival across different histocompatibility MHC barriers
The immunosuppressive effect of FTY720 is associated with the reversible sequestration of
lymphocytes from the blood and the spleen into secondary lymphoid organs and reduced …
lymphocytes from the blood and the spleen into secondary lymphoid organs and reduced …
Manipulation of dendritic cell migration and function in relation to alloimmune reactivity and transplant outcome
YY Lan - 2006 - search.proquest.com
The immediate challenge of transplant immunology is to induce donor-specific immune
tolerance to improve graft outcome and to eliminate the need for dependency on …
tolerance to improve graft outcome and to eliminate the need for dependency on …
[CITATION][C] The In Vitro Effects of Biomaterials on Lymphocyte Responses to an Allogeneic Challenge
N Farooqui - 2006