Over the past two decades, research has identified extrasynaptic GABA A receptor
populations that enable neurons to sense the low ambient GABA concentrations present in …

The past decade has brought many advances in our understanding of GABA A receptor-
mediated ethanol action in the central nervous system. We now know that specific GABA A …

Abstract The Concise Guide to PHARMACOLOGY 2013/14 provides concise overviews of
the key properties of over 2000 human drug targets with their pharmacology, plus links to an …

Adaptation of the nervous system to different chemical and physiologic conditions is
important for the homeostasis of brain processes and for learning and remembering …

There is substantial evidence that GABAergic neurotransmission is important for many
behavioral actions of ethanol and there are reports spanning more than 30 years of literature …

Ethanol produces a wide variety of behavioral and physiological effects in the body, but
exactly how it acts to produce these effects is still poorly understood. Although ethanol was …

Alcoholism is a common, heritable, chronic relapsing disorder. GABAA receptors undergo
allosteric modulation by ethanol, anesthetics, benzodiazepines and neurosteroids and have …

Neurosteroids represent a class of endogenous steroids that are synthesized in the brain,
the adrenals, and the gonads and have potent and selective effects on the GABAA-receptor …

The development of alcohol dependence is posited to involve numerous changes in brain
chemistry (ie, neurotransmission) that lead to physiological signs of withdrawal upon …

GABAA receptors form the major class of inhibitory neurotransmitter receptors in the
mammalian brain. This review sets out to summarize the evidence that variations in genes …