Chemokines are an indispensable component of our immune system through the regulation
of directional migration and activation of leukocytes. CXCL8 is the most potent human …

Sepsis is a persistent systemic inflammatory condition involving multiple organ failures
resulting from a dysregulated immune response to infection, and one of the hallmarks of …

Sepsis is a life-threatening clinical syndrome characterized by multiorgan dysfunction
caused by a dysregulated or over-reactive host response to infection. During sepsis, the …

Neutrophil extracellular traps (NETs), crucial in immune defense mechanisms, are
renowned for their propensity to expel decondensed chromatin embedded with inflammatory …

Neutrophil extracellular traps (NETs), released by polymorphonuclear neutrophils (PMNs),
exert a robust antimicrobial function in infectious diseases such as sepsis. NETs also …

Neutrophils are among the most abundant immune cells, representing about 50%− 70% of
all circulating leukocytes in humans. Neutrophils rapidly infiltrate inflamed tissues and play …

Evidence shows that neutrophils can protect the host against pathogens in multiple ways,
including the formation and release of neutrophil extracellular traps (NETs). NETs are web …

Neutrophil extracellular traps (NETs) are large DNA reticular structures secreted by
neutrophils and decorated with histones and antimicrobial proteins. As a key mechanism for …

Neutrophils are the first cells to be recruited to sites of acute inflammation and contribute to
host defense through phagocytosis, degranulation and neutrophil extracellular traps (NETs) …

Background Excess polymorphonuclear neutrophil (PMN) recruitment or excessive
neutrophil extracellular trap (NET) formation can lead to the development of multiple organ …