G9a/GLP Modulators: Inhibitors to Degraders

A Mukherjee, T Suzuki - Journal of Medicinal Chemistry, 2025 - ACS Publications
Histone methylation, a crucial aspect of epigenetics, intricately involves specialized
enzymes such as G9a, a histone methyltransferase (HMT) catalyzing the methylation of …

G9a an Epigenetic Therapeutic Strategy for Neurodegenerative Conditions: From Target Discovery to Clinical Trials

A Bellver‐Sanchis, M Ribalta‐Vilella… - Medicinal Research …, 2025 - Wiley Online Library
This review provides a comprehensive overview of the role of G9a/EHMT2, focusing on its
structure and exploring the impact of its pharmacological and/or gene inhibition in various …