In recent years considerable progress has been made in the development of faithful
procedures for the differentiation of human pluripotent stem cells (hPSCs). An important step …

Cells exert, sense, and respond to physical forces through an astounding diversity of
mechanisms. Here we review recently developed tools to quantify the forces generated by …

Understanding how SARS-CoV-2 spreads within the respiratory tract is important to define
the parameters controlling the severity of COVID-19. Here we examine the functional and …

Fluorescence microscopy is a key driver of discoveries in the life sciences, with observable
phenomena being limited by the optics of the microscope, the chemistry of the fluorophores …

A long-term aim of the life sciences is to understand how organismal shape is encoded by
the genome. An important challenge is to identify mechanistic links between the genes that …

We introduce an Active Vertex Model (AVM) for cell-resolution studies of the mechanics of
confluent epithelial tissues consisting of tens of thousands of cells, with a level of detail …

The name active matter refers to any collection of entities that individually use free energy to
generate their own motion and forces. Through interactions, active particles spontaneously …

How do genes modify cellular growth to create morphological diversity? We study this
problem in two related plants with differently shaped leaves: Arabidopsis thaliana (simple …

Cell packing—the spatial arrangement of cells—determines the shapes of organs. Recently,
investigations of organ development in a variety of model organisms have uncovered …

Studying how epithelia respond to mechanical stresses is key to understanding tissue shape
changes during morphogenesis. Here, we study the viscoelastic properties of the Drosophila …