CAFs interacting with TAMs in tumor microenvironment to enhance tumorigenesis and immune evasion
Cancer associated fibroblasts (CAFs) and tumor associated macrophages (TAMs) are
among the most important and abundant players of the tumor microenvironment. CAFs as …
among the most important and abundant players of the tumor microenvironment. CAFs as …
Activation induced cytidine deaminase: An old friend with new faces
Activation induced cytidine deaminase (AID) protein is a member of APOBEC family. AID
converts cytidine to uracil, which is a key step for somatic hypermutation (SHM) and class …
converts cytidine to uracil, which is a key step for somatic hypermutation (SHM) and class …
Constructing a novel mitochondrial-related gene signature for evaluating the tumor immune microenvironment and predicting survival in stomach adenocarcinoma
Background The incidence and mortality of gastric cancer ranks fifth and fourth worldwide
among all malignancies, respectively. Accumulating evidences have revealed the close …
among all malignancies, respectively. Accumulating evidences have revealed the close …
Photodynamic therapy improves the clinical efficacy of advanced colorectal cancer and recruits immune cells into the tumor immune microenvironment
Objective Although photodynamic therapy (PDT) has been proven effective in various
tumors, it has not been widely used as a routine treatment for colorectal cancer (CRC), and …
tumors, it has not been widely used as a routine treatment for colorectal cancer (CRC), and …
Epigenetic modifications in tumor-associated macrophages: A new perspective for an old foe
Y Niu, J Chen, Y Qiao - Frontiers in Immunology, 2022 - frontiersin.org
Tumorigenesis is frequently accompanied by chronic inflammation, and the tumor
microenvironment (TME) can be considered an ecosystem that consists of tumor cells …
microenvironment (TME) can be considered an ecosystem that consists of tumor cells …
Immunometabolism–the role of branched-chain amino acids
Immunometabolism has been the focus of extensive research over the last years, especially
in terms of augmenting anti-tumor immune responses. Regulatory T cells (Tregs) are a …
in terms of augmenting anti-tumor immune responses. Regulatory T cells (Tregs) are a …
Spatial analysis of stromal signatures identifies invasive front carcinoma-associated fibroblasts as suppressors of anti-tumor immune response in esophageal cancer
Background Increasing evidence indicates that the tumor microenvironment (TME) is a
crucial determinant of cancer progression. However, the clinical and pathobiological …
crucial determinant of cancer progression. However, the clinical and pathobiological …
Dynamic changes in myofibroblasts affect the carcinogenesis and prognosis of bladder cancer associated with tumor microenvironment remodeling
YH Du, YQ Sui, J Cao, X Jiang, Y Wang, J Yu… - Frontiers in Cell and …, 2022 - frontiersin.org
Bladder cancer (BLCA) is a tumor that possesses significant heterogeneity, and the tumor
microenvironment (TME) plays an important role in the development of BLCA. The TME …
microenvironment (TME) plays an important role in the development of BLCA. The TME …
[HTML][HTML] Modulation of AMPK significantly alters uveal melanoma tumor cell viability
Introduction: Uveal melanoma (UM) responds poorly to targeted therapies or immune
checkpoint inhibitors. Adenosine monophosphate-activated protein kinase (AMPK) is a …
checkpoint inhibitors. Adenosine monophosphate-activated protein kinase (AMPK) is a …
[PDF][PDF] The influence of stromal fibroblast on antigen-presenting cell function and alteration of their biology
S Mohammad - eprints.nottingham.ac.uk
Dendritic cells (DC) and macrophages (Mɸ) are antigen presenting cells (APC) that
orchestrate immune activation, immune and tissue homeostasis, and disease pathology. In …
orchestrate immune activation, immune and tissue homeostasis, and disease pathology. In …