Carbonic anhydrase and bacterial metabolism: a chance for antibacterial drug discovery
ABSTRACT Introduction Carbonic anhydrases (CAs, EC 4.2. 1.1) play a pivotal role in the
regulation of carbon dioxide, bicarbonate, and hydrogen ions within bacterial cells, ensuring …
regulation of carbon dioxide, bicarbonate, and hydrogen ions within bacterial cells, ensuring …
[HTML][HTML] An overview of the bacterial carbonic anhydrases
Bacteria encode carbonic anhydrases (CAs, EC 4.2. 1.1) belonging to three different genetic
families, the α-, β-, and γ-classes. By equilibrating CO2 and bicarbonate, these …
families, the α-, β-, and γ-classes. By equilibrating CO2 and bicarbonate, these …
An overview of novel antimicrobial carbonic anhydrase inhibitors
Introduction Four different genetic families of the enzyme carbonic anhydrase (CA, EC 4.2.
1.1) are present in bacteria, α-, β-, γ-and ι-CAs. They play relevant functions related to CO2 …
1.1) are present in bacteria, α-, β-, γ-and ι-CAs. They play relevant functions related to CO2 …
Antibacterial carbonic anhydrase inhibitors: an update on the recent literature
Introduction The clinically licensed drugs used as antibiotics prevent the microbial growth
interfering with the biosynthesis of proteins, nucleic acids, microorganism wall biosynthesis …
interfering with the biosynthesis of proteins, nucleic acids, microorganism wall biosynthesis …
Multi-and poly-pharmacology of carbonic anhydrase inhibitors
Eight genetically distinct families of the enzyme carbonic anhydrase (CA, EC 4.2. 1.1) were
described in organisms allover the phylogenetic tree. They catalyze the hydration of CO 2 to …
described in organisms allover the phylogenetic tree. They catalyze the hydration of CO 2 to …
Antibiofilm and Anti-Quorum-Sensing Activities of Novel Pyrazole and Pyrazolo[1,5-a]pyrimidine Derivatives as Carbonic Anhydrase I and II Inhibitors: Design …
Nowadays, searching for new anti-infective agents with diverse mechanisms of action has
become necessary. In this study, 16 pyrazole and pyrazolo [1, 5-a] pyrimidine derivatives …
become necessary. In this study, 16 pyrazole and pyrazolo [1, 5-a] pyrimidine derivatives …
Carbonic anhydrase inhibitors as novel antibacterials in the era of antibiotic resistance: where are we now?
Resistance to antibiotic treatment developed by bacteria in humans and animals occurs
when the microorganisms resist treatment with clinically approved antibiotics. Actions must …
when the microorganisms resist treatment with clinically approved antibiotics. Actions must …
Carbonic Anhydrases: New Perspectives on Protein Functional Role and Inhibition in Helicobacter pylori
Our understanding of the function of bacterial carbonic anhydrases (CAs, EC 4.2. 1.1) has
increased significantly in the last years. CAs are metalloenzymes able to modulate CO2 …
increased significantly in the last years. CAs are metalloenzymes able to modulate CO2 …
Synthesis of 4, 5-disubstituted-2-thioxo-1, 2, 3, 4-tetrahydropyrimidines and investigation of their acetylcholinesterase, butyrylcholinesterase, carbonic anhydrase I/II …
A series of tetrahydropyrimidinethiones were synthesized from thiourea, β-diketones and
aromatic aldehydes, such as p-tolualdehyde, p-anisaldehyde, o-tolualdehyde …
aromatic aldehydes, such as p-tolualdehyde, p-anisaldehyde, o-tolualdehyde …
Biomedical applications of prokaryotic carbonic anhydrases
Introduction: The hydration/dehydration of CO2 catalyzed by carbonic anhydrases (CAs, EC
4.2. 1.1) is a crucial physiological reaction for the survival of all living organisms because it …
4.2. 1.1) is a crucial physiological reaction for the survival of all living organisms because it …