Soluble N-ethylmaleimide-sensitive factor attachment protein receptors (SNAREs) are a
family of small conserved eukaryotic proteins that mediate membrane fusion between …

Membrane fusion is a key process in all living organisms that contributes to a variety of
biological processes including viral infection, cell fertilization, as well as intracellular …

Hierarchical organization of integral membrane proteins (IMP) and lipids at the membrane is
essential for regulating myriad downstream signaling. A quantitative understanding of these …

Soluble N-ethylmaleimide–sensitive factor attachment protein receptor (SNARE) proteins
drive membrane fusion by assembling into a four-helix bundle in a zippering process. Here …

Abstract α-Synuclein (α-Syn) aggregation is closely associated with Parkinson's disease
neuropathology. Physiologically, α-Syn promotes synaptic vesicle (SV) clustering and …

Following phagocytosis, the nascent phagosome undergoes maturation to become a
phagolysosome with an acidic, hydrolytic, and often oxidative lumen that can efficiently kill …

SNAREs provide a large part of the specificity and energy needed for membrane fusion and,
to do so, must be localized to their correct membranes. Here, we show that the R-SNAREs …

Complexin prevents SNAREs from releasing neurotransmitters until an action potential
arrives at the synapse. To understand the mechanism for this inhibition, we determined the …

SNARE molecules are the core constituents of the protein machinery that facilitate fusion of
synaptic vesicles with the presynaptic plasma membrane, resulting in the release of …

The revolution in genetic technology has ushered in a new age for our understanding of the
underlying causes of neurodevelopmental, neuromuscular and neurodegenerative …