[HTML][HTML] The day-to-day practice of MMR and MSI assessment in colorectal adenocarcinoma: what we know and what we still need to explore
P Parente, F Grillo, A Vanoli, MC Macciomei… - Digestive …, 2023 - karger.com
Background: The DNA mismatch repair (MMR) system is a highly preserved protein complex
recognizing short insertions, short deletions, and single base mismatches during DNA …
recognizing short insertions, short deletions, and single base mismatches during DNA …
The role of the pathologist in the next-generation era of tumor molecular characterization
Current pathology practice is being shaped by the increasing complexity of modern
medicine, in particular of precision oncology, and major technological advances. In the “next …
medicine, in particular of precision oncology, and major technological advances. In the “next …
Association of CLDN18 protein expression with clinicopathological features and prognosis in advanced gastric and gastroesophageal junction adenocarcinomas
A Pellino, S Brignola, E Riello, M Niero… - Journal of Personalized …, 2021 - mdpi.com
Simple Summary Claudin-18 is a tight junction protein expressed in various cancer types
including gastric and gastroesophageal junction cancer. The claudin-18.2 isoform …
including gastric and gastroesophageal junction cancer. The claudin-18.2 isoform …
PD-L1 evaluation in the gastrointestinal tract: from biological rationale to its clinical application
Immune-checkpoint inhibitors targeting the PD-1/PD-L1 axis have brought significant clinical
benefit in many solid cancer types, including gastrointestinal malignancies. However, it has …
benefit in many solid cancer types, including gastrointestinal malignancies. However, it has …
[HTML][HTML] Evaluation of micro satellite instability and mismatch repair status in different solid tumors: a multicenter analysis in a real world setting
Immune-checkpoint inhibitors (ICIs) play a key role in the treatment of advanced stage
colorectal cancer (CRC) patients featuring a deficient DNA mismatch repair (dMMR) system …
colorectal cancer (CRC) patients featuring a deficient DNA mismatch repair (dMMR) system …
[HTML][HTML] Prognostic impact of FGFR2/3 alterations in patients with biliary tract cancers receiving systemic chemotherapy: the BITCOIN study
M Rizzato, S Brignola, G Munari, M Gatti… - European Journal of …, 2022 - Elsevier
Aim FGFR2 rearrangements have been identified as a novel therapeutic target of biliary tract
cancer (BTC). However, reliable prevalence estimates of this molecular alteration and its …
cancer (BTC). However, reliable prevalence estimates of this molecular alteration and its …
[HTML][HTML] FFPE-based NGS approaches into clinical practice: the limits of glory from a pathologist viewpoint
F Cappello, V Angerilli, G Munari, C Ceccon… - Journal of Personalized …, 2022 - mdpi.com
The introduction of next-generation sequencing (NGS) in the molecular diagnostic
armamentarium is deeply changing pathology practice and laboratory frameworks. NGS …
armamentarium is deeply changing pathology practice and laboratory frameworks. NGS …
HER2-low in gastro-oesophageal adenocarcinoma: A real-world pathological perspective
Aims In the DESTINY-Gastric01 trial, a novel HER2-targeted antibody-drug conjugate
trastuzumab deruxtecan proved to be effective in HER2-low gastro-oesophageal …
trastuzumab deruxtecan proved to be effective in HER2-low gastro-oesophageal …
Evaluating mismatch repair deficiency in colorectal cancer biopsy specimens
Mismatch repair (MMR) testing on all new cases of colorectal cancer (CRC) has customarily
been preferably performed on surgical specimens, as more tissue is available; however …
been preferably performed on surgical specimens, as more tissue is available; however …
[HTML][HTML] mRNA vaccine in gastrointestinal tumors: Immunomodulatory effects and immunotherapy
A Zhang, Q Ji, X Sheng, H Wu - Biomedicine & Pharmacotherapy, 2023 - Elsevier
Gastrointestinal tumors remain a significant healthcare burden worldwide, necessitating the
development of innovative therapeutic strategies. mRNA vaccines have emerged as a …
development of innovative therapeutic strategies. mRNA vaccines have emerged as a …