BACKGROUND Adaptation of the maternal immune response to accommodate the semi-
allogeneic fetus is necessary for pregnancy success, and disturbances in maternal tolerance …

In clinical infertility practice, one intractable problem is low (or absent) ovarian reserve which
in turn reflects the natural oocyte depletion associated with advancing maternal age. The …

Purpose: The forkhead box transcription factor FoxP3 is specifically expressed in T cells with
regulatory properties (Treg). Recently, high numbers of Treg were described to be …

The CD4+ T cell‐mediated inflammatory response to Pneumocystis carinii (PC) critically
contributes to the clinical severity of PC pneumonia. It has been suggested that lymphopenic …

CD25+ 4+ regulatory T cells (Treg) play an indispensable role in preventing autoimmunity.
Little is known, however, about the antigen specificities required for their development and …

Exploring stem cells in the mammalian ovary has unleashed a Pandora's box of new
insights and questions. Recent evidence supports the existence of stem cells of a number of …

This study investigated the unresolved issue of antigen-dependency and antigen-specificity
of autoimmune disease suppression by CD4+ CD25+ T cells (T regs). Based on …

BACKGROUND: Mater is a maternal effect gene required for early embryonic development
in mice, and its protein serves as an autoantigen in a mouse model of autoimmune …

The principal role of the immune system is to monitor and defend the integrity of the
organism. Immune cells act to recognize and usually repel invaders of all types, from …

Infertility affects one in six couples worldwide, with more than 48 million couples affected
internationally. The prevalence of infertility is increasing which is thought to be attributed to …