[HTML][HTML] Molecular pathways involved in COVID-19 and potential pathway-based therapeutic targets
Deciphering the molecular downstream consequences of severe acute respiratory
syndrome coronavirus (SARS-CoV)− 2 infection is important for a greater understanding of …
syndrome coronavirus (SARS-CoV)− 2 infection is important for a greater understanding of …
Ischemia/reperfusion injury revisited: an overview of the latest pharmacological strategies
ROS Soares, DM Losada, MC Jordani, P Évora… - International journal of …, 2019 - mdpi.com
Ischemia/reperfusion injury (IRI) permeates a variety of diseases and is a ubiquitous
concern in every transplantation proceeding, from whole organs to modest grafts. Given its …
concern in every transplantation proceeding, from whole organs to modest grafts. Given its …
Nose to brain drug delivery-a promising strategy for active components from herbal medicine for treating cerebral ischemia reperfusion
Y Long, Q Yang, Y **ang, Y Zhang, J Wan, S Liu… - Pharmacological …, 2020 - Elsevier
Cerebral ischemia reperfusion injury (CIRI), one of the major causes of death from stroke in
the world, not only causes tremendous damage to human health, but also brings heavy …
the world, not only causes tremendous damage to human health, but also brings heavy …
MicroRNA-124 regulates the expression of MEKK3 in the inflammatory pathogenesis of Parkinson's disease
L Yao, Y Ye, H Mao, F Lu, X He, G Lu… - Journal of …, 2018 - Springer
Background Parkinson's disease (PD) is the most prevalent neurodegenerative disorder that
is characterised by selective loss of midbrain dopaminergic (DA) neurons. Chronic …
is characterised by selective loss of midbrain dopaminergic (DA) neurons. Chronic …
miRNA involvement in cerebral ischemia-reperfusion injury
Cerebral ischemia reperfusion injury is a debilitating medical condition, currently with only a
limited amount of therapies aimed at protecting the cerebral parenchyma. Micro RNAs …
limited amount of therapies aimed at protecting the cerebral parenchyma. Micro RNAs …
Rabies virus glycoprotein (RVG29)-linked microRNA-124-loaded polymeric nanoparticles inhibit neuroinflammation in a Parkinson's disease model
L Gan, Z Li, Q Lv, W Huang - International journal of pharmaceutics, 2019 - Elsevier
In the present study, we have prepared microRNA (miR)-124-loaded Rabies virus
glycoprotein (RVG) 29 surface-conjugated polymeric nanoparticles (NPs) to improve …
glycoprotein (RVG) 29 surface-conjugated polymeric nanoparticles (NPs) to improve …
LRRK2 regulates ferroptosis through the system Xc‐GSH–GPX4 pathway in the neuroinflammatory mechanism of Parkinson's disease
Z Zheng, S Zhang, X Liu, X Wang, C Xue… - Journal of Cellular …, 2024 - Wiley Online Library
Parkinson's disease (PD) is the most prevalent neurodegenerative disorder.
Neuroinflammation mediated by activated microglia and apoptosis of dopaminergic (DA) …
Neuroinflammation mediated by activated microglia and apoptosis of dopaminergic (DA) …
Ulinastatin ameliorates pulmonary capillary endothelial permeability induced by sepsis through protection of tight junctions via inhibition of TNF-α and related …
M Fang, W Zhong, W Song, Y Deng, D Yang… - Frontiers in …, 2018 - frontiersin.org
Background: Increased permeability of pulmonary capillary is a common consequence of
sepsis that leads to acute lung injury. In this connection, ulinastatin, a urinary trypsin inhibitor …
sepsis that leads to acute lung injury. In this connection, ulinastatin, a urinary trypsin inhibitor …
Rosmarinic acid mitigates lipopolysaccharide-induced neuroinflammatory responses through the inhibition of TLR4 and CD14 expression and NF-κB and NLRP3 …
Y Wei, J Chen, Y Hu, W Lu, X Zhang, R Wang, K Chu - Inflammation, 2018 - Springer
The excessive activation of microglia plays a key role in the pathogenesis of
neurodegenerative diseases. The neuroprotective properties of rosmarinic acid have been …
neurodegenerative diseases. The neuroprotective properties of rosmarinic acid have been …
Central noradrenergic agonists in the treatment of ischemic stroke—an overview
Z Sternberg, B Schaller - Translational stroke research, 2020 - Springer
Ischemic stroke is the leading cause of morbidity and mortality with a significant health
burden worldwide and few treatment options. Among the short-and long-term effects of …
burden worldwide and few treatment options. Among the short-and long-term effects of …