Invasive fungal infections are a leading global cause of human mortality. Only three major
classes of antifungal drugs are widely used, and resistance to all three classes can arise …

In this review, I explore the pervasive but underappreciated role of local adaptation in fungi.
It has been difficult historically to study local adaptation in fungi because of the limited …

Mutation is the origin of all genetic variation, good and bad. The mutation process can
evolve in response to mutations, positive or negative selection, and genetic drift, but how …

A number of in vitro studies have examined the acquisition of drug resistance to the triazole
fluconazole, a first-line treatment for many Candida infections. Much less is known about …

Background The great diversity of lifestyles and survival strategies observed in fungi is
reflected in the many ways in which they reproduce and recombine. Although a complete …

Ploidy is an evolutionarily labile trait, and its variation across the tree of life has profound
impacts on evolutionary trajectories and life histories. The immediate consequences and …

All adaptive alleles in existence today began as mutations, but a common view in ecology,
evolution, and genetics is that non-neutral mutations are much more likely to be deleterious …

The appearance of genomic variations such as loss of heterozygosity (LOH) has a
significant impact on phenotypic diversity observed in a population. Recent large-scale …

Premise Theory predicts that mixed ploidy populations should be short‐lived due to strong
fitness disadvantages for the rare ploidy. However, mixed ploidy populations are common …

The experimental evolution of microorganisms exposed to extreme conditions can provide
insight into cellular adaptation to stress. Typically, stress-sensitive species are exposed to …