Quillaja saponaria Molina represents the main source of saponins for industrial applications.
Q. saponaria triterpenoids have been studied for more than four decades and their …

Saponins are extracted from different parts of plants such as seeds, roots, stems, and leaves
and have a variety of biological activities including immunomodulatory, anti-inflammatory …

Implementation of inactivated polio vaccines (IPV) containing Sabin strains (sIPV) will further
enable global polio eradication efforts by improving vaccine safety during use and …

Most pathogens gain access to the human body and initiate systemic infections through
mucosal sites. A large number of currently marketed licensed vaccines are parenterally …

There is an urgent need for a safe, efficacious, and cost-effective vaccine for the coronavirus
disease 2019 (COVID-19) pandemic caused by novel coronavirus strain, severe acute …

The SARS-CoV-2 outbreak has posed a plethora of problems for the global healthcare
system and socioeconomic burden. Despite valiant efforts to contain the COVID-19 …

The virus-like particle (VLP) platform is a robust inducer of humoral and cellular immune
responses; hence, it has been used in vaccine development for several infectious diseases …

In the last decades, significant efforts have been dedicated to the search for novel vaccine
adjuvants. In this regard, saponins and its formulations as “immunostimulating …

Commercially available saponins are extracted from Quillaja saponaria barks, being Quil A®
the most widely used. Nanoparticulate immunostimulating complexes (ISCOMs or …

Saponin-based adjuvants are promising adjuvants that enhance both humoral and T-cell-
mediated immunity. One of the most used natural products as vaccine adjuvants are Quillaja …