Single-cell genome sequencing: current state of the science
The field of single-cell genomics is advancing rapidly and is generating many new insights
into complex biological systems, ranging from the diversity of microbial ecosystems to the …
into complex biological systems, ranging from the diversity of microbial ecosystems to the …
Advances and applications of single-cell sequencing technologies
Single-cell sequencing (SCS) has emerged as a powerful new set of technologies for
studying rare cells and delineating complex populations. Over the past 5 years, SCS …
studying rare cells and delineating complex populations. Over the past 5 years, SCS …
Advancing cancer research and medicine with single-cell genomics
Single-cell sequencing (SCS) has impacted many areas of cancer research and improved
our understanding of intratumor heterogeneity, the tumor microenvironment, metastasis, and …
our understanding of intratumor heterogeneity, the tumor microenvironment, metastasis, and …
Tumor evolution: Linear, branching, neutral or punctuated?
Intratumor heterogeneity has been widely reported in human cancers, but our knowledge of
how this genetic diversity emerges over time remains limited. A central challenge in studying …
how this genetic diversity emerges over time remains limited. A central challenge in studying …
Mosaic copy number variation in human neurons
We used single-cell genomic approaches to map DNA copy number variation (CNV) in
neurons obtained from human induced pluripotent stem cell (hiPSC) lines and postmortem …
neurons obtained from human induced pluripotent stem cell (hiPSC) lines and postmortem …
The first five years of single-cell cancer genomics and beyond
NE Navin - Genome research, 2015 - genome.cshlp.org
Single-cell sequencing (SCS) is a powerful new tool for investigating evolution and diversity
in cancer and understanding the role of rare cells in tumor progression. These methods …
in cancer and understanding the role of rare cells in tumor progression. These methods …
Single cell isolation and analysis
P Hu, W Zhang, H **n, G Deng - Frontiers in cell and developmental …, 2016 - frontiersin.org
Individual cell heterogeneity within a population can be critical to its peculiar function and
fate. Subpopulations studies with mixed mutants and wild types may not be as informative …
fate. Subpopulations studies with mixed mutants and wild types may not be as informative …
Understanding tumor ecosystems by single-cell sequencing: promises and limitations
Cellular heterogeneity within and across tumors has been a major obstacle in
understanding and treating cancer, and the complex heterogeneity is masked if bulk tumor …
understanding and treating cancer, and the complex heterogeneity is masked if bulk tumor …
Single cell genomics: advances and future perspectives
IC Macaulay, T Voet - PLoS genetics, 2014 - journals.plos.org
Advances in whole-genome and whole-transcriptome amplification have permitted the
sequencing of the minute amounts of DNA and RNA present in a single cell, offering a …
sequencing of the minute amounts of DNA and RNA present in a single cell, offering a …
Cancer genomics: one cell at a time
NE Navin - Genome biology, 2014 - Springer
The study of single cancer cells has transformed from qualitative microscopic images to
quantitative genomic datasets. This paradigm shift has been fueled by the development of …
quantitative genomic datasets. This paradigm shift has been fueled by the development of …