The human liver is usually perceived as a non-immunological organ engaged primarily in
metabolic, nutrient storage and detoxification activities. However, we now know that the …

The liver is a central immunological organ with a high exposure to circulating antigens and
endotoxins from the gut microbiota, particularly enriched for innate immune cells …

Neuropilins (NRPs) are non-tyrosine kinase cell surface glycoproteins expressed in all
vertebrates and widely conserved across species. The two isoforms, such as neuropilin-1 …

The liver is a tolerogenic organ with exquisite mechanisms of immune regulation that ensure
upkeep of local and systemic immune tolerance to self and foreign antigens, but that is also …

Current systemic treatment options for patients with hepatocellular carcinoma (HCC) are
limited to sorafenib. With the recent FDA approval of the second PD1-PD-L1 pathway …

Localization of memory CD8+ T cells to lymphoid or peripheral tissues is believed to
correlate with proliferative capacity or effector function. Here we demonstrate that the …