Human development requires intricate cell specification and communication pathways that
allow an embryo to generate and appropriately connect more than 200 different cell types …

Autophagy and the ubiquitin–proteasome system (UPS) are the two major intracellular
quality control and recycling mechanisms that are responsible for cellular homeostasis in …

The ribosome has recently transitioned from being viewed as a passive, indiscriminate
machine to a more dynamic macromolecular complex with specialized roles in the cell …

Aberrantly slow translation elicits quality control pathways initiated by the ubiquitin ligase
ZNF598. How ZNF598 discriminates physiologic from pathologic translation complexes and …

Ubiquitylation is an essential posttranslational modification that controls cell division,
differentiation, and survival in all eukaryotes. By combining multiple E3 ligases (writers) …

Protein synthesis by the ribosome can fail for numerous reasons including faulty mRNA,
insufficient availability of charged tRNAs and genetic errors. All organisms have evolved …

The accumulation of stalled translation preinitiation complexes (PICs) mediates the
condensation of stress granules (SGs). Interactions between prion-related domains and …

Translation arrest by polybasic sequences induces ribosome stalling, and the arrest product
is degraded by the ribosome-mediated quality control (RQC) system. Here we report that …

Ribosomes that experience terminal stalls during translation are resolved by ribosome-
associated quality control (QC) pathways that oversee mRNA and nascent chain destruction …

Diverse cellular stressors have been observed to trigger site-specific ubiquitination on
several ribosomal proteins. However, the ubiquitin ligases, biochemical consequences, and …