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NMR metabolomics methods for investigating disease
The field of metabolomics continues to grow exponentially as it contributes significantly to
numerous disciplines, including biomedicine, pharmacology, drug development, and …
numerous disciplines, including biomedicine, pharmacology, drug development, and …
Recent advances in the application of parahydrogen in catalysis and biochemistry
G Buntkowsky, F Theiss, J Lins, YA Miloslavina… - RSC …, 2022 - pubs.rsc.org
Nuclear Magnetic Resonance (NMR) spectroscopy and Magnetic Resonance Imaging (MRI)
are analytical and diagnostic tools that are essential for a very broad field of applications …
are analytical and diagnostic tools that are essential for a very broad field of applications …
Nitrogen-15 dynamic nuclear polarization of nicotinamide derivatives in biocompatible solutions
Dissolution dynamic nuclear polarization (dDNP) increases the sensitivity of magnetic
resonance imaging by more than 10,000 times, enabling in vivo metabolic imaging to be …
resonance imaging by more than 10,000 times, enabling in vivo metabolic imaging to be …
Parahydrogen Hyperpolarization Allows Direct NMR Detection of α‐Amino Acids in Complex (Bio) mixtures
The scope of non‐hydrogenative parahydrogen hyperpolarization (nhPHIP) techniques has
been expanding over the last years, with the continuous addition of important classes of …
been expanding over the last years, with the continuous addition of important classes of …
Parahydrogen-based NMR signal amplification by reversible exchange (SABRE): Recent advances and applications
Signal amplification by reversible exchange (SABRE) is a rapidly develo** nuclear
magnetic resonance (NMR) hyperpolarization technique utilizing parahydrogen for dramatic …
magnetic resonance (NMR) hyperpolarization technique utilizing parahydrogen for dramatic …
Selective isotope labeling and LC-photo-CIDNP enable NMR spectroscopy at low-nanomolar concentration
H Yang, S Li, CA Mickles, V Guzman-Luna… - Journal of the …, 2022 - ACS Publications
NMR spectroscopy is a powerful tool to investigate molecular structure and dynamics. The
poor sensitivity of this technique, however, limits its ability to tackle questions requiring dilute …
poor sensitivity of this technique, however, limits its ability to tackle questions requiring dilute …
Enhancing sensitivity of nuclear magnetic resonance in biomolecules: Parahydrogen-induced hyperpolarization in synthetic disulfide-rich miniproteins
J Lins, YA Miloslavina, O Avrutina… - Journal of the …, 2024 - ACS Publications
Hyperpolarization of small peptides by parahydrogen-induced polarization (PHIP) to
increase the sensitivity of nuclear magnetic resonance (NMR) techniques is well …
increase the sensitivity of nuclear magnetic resonance (NMR) techniques is well …
Understanding heterogeneous catalytic hydrogenation by parahydrogen-induced polarization NMR spectroscopy
Parahydrogen-induced polarization (PHIP) is an NMR hyperpolarization technique with the
ability to increase the NMR sensitivity by serval orders. The generation of hyperpolarization …
ability to increase the NMR sensitivity by serval orders. The generation of hyperpolarization …
Modern manufacturing enables magnetic field cycling experiments and parahydrogen-induced hyperpolarization with a benchtop NMR
Benchtop NMR (btNMR) spectrometers are revolutionizing the way we use NMR and
lowering the cost drastically. Magnetic field cycling (MFC) experiments with precise timing …
lowering the cost drastically. Magnetic field cycling (MFC) experiments with precise timing …
Reversible Parahydrogen Induced Hyperpolarization of 15N in Unmodified Amino Acids Unraveled at High Magnetic Field
Amino acids (AAs) and ammonia are metabolic markers essential for nitrogen metabolism
and cell regulation in both plants and humans. NMR provides interesting opportunities to …
and cell regulation in both plants and humans. NMR provides interesting opportunities to …