NMR metabolomics methods for investigating disease

GA Nagana Gowda, D Raftery - Analytical chemistry, 2023 - ACS Publications
The field of metabolomics continues to grow exponentially as it contributes significantly to
numerous disciplines, including biomedicine, pharmacology, drug development, and …

Recent advances in the application of parahydrogen in catalysis and biochemistry

G Buntkowsky, F Theiss, J Lins, YA Miloslavina… - RSC …, 2022 - pubs.rsc.org
Nuclear Magnetic Resonance (NMR) spectroscopy and Magnetic Resonance Imaging (MRI)
are analytical and diagnostic tools that are essential for a very broad field of applications …

Nitrogen-15 dynamic nuclear polarization of nicotinamide derivatives in biocompatible solutions

JP Peters, A Brahms, V Janicaud, M Anikeeva… - Science …, 2023 - science.org
Dissolution dynamic nuclear polarization (dDNP) increases the sensitivity of magnetic
resonance imaging by more than 10,000 times, enabling in vivo metabolic imaging to be …

Parahydrogen Hyperpolarization Allows Direct NMR Detection of α‐Amino Acids in Complex (Bio) mixtures

L Sellies, RLEG Aspers, MC Feiters… - Angewandte …, 2021 - Wiley Online Library
The scope of non‐hydrogenative parahydrogen hyperpolarization (nhPHIP) techniques has
been expanding over the last years, with the continuous addition of important classes of …

Parahydrogen-based NMR signal amplification by reversible exchange (SABRE): Recent advances and applications

OG Salnikov, DB Burueva, IV Skovpin… - Mendeleev …, 2023 - Elsevier
Signal amplification by reversible exchange (SABRE) is a rapidly develo** nuclear
magnetic resonance (NMR) hyperpolarization technique utilizing parahydrogen for dramatic …

Selective isotope labeling and LC-photo-CIDNP enable NMR spectroscopy at low-nanomolar concentration

H Yang, S Li, CA Mickles, V Guzman-Luna… - Journal of the …, 2022 - ACS Publications
NMR spectroscopy is a powerful tool to investigate molecular structure and dynamics. The
poor sensitivity of this technique, however, limits its ability to tackle questions requiring dilute …

Enhancing sensitivity of nuclear magnetic resonance in biomolecules: Parahydrogen-induced hyperpolarization in synthetic disulfide-rich miniproteins

J Lins, YA Miloslavina, O Avrutina… - Journal of the …, 2024 - ACS Publications
Hyperpolarization of small peptides by parahydrogen-induced polarization (PHIP) to
increase the sensitivity of nuclear magnetic resonance (NMR) techniques is well …

Understanding heterogeneous catalytic hydrogenation by parahydrogen-induced polarization NMR spectroscopy

W Wang, Q Wang, J Xu, F Deng - ACS Catalysis, 2023 - ACS Publications
Parahydrogen-induced polarization (PHIP) is an NMR hyperpolarization technique with the
ability to increase the NMR sensitivity by serval orders. The generation of hyperpolarization …

Modern manufacturing enables magnetic field cycling experiments and parahydrogen-induced hyperpolarization with a benchtop NMR

F Ellermann, P Saul, JB Hövener… - Analytical …, 2023 - ACS Publications
Benchtop NMR (btNMR) spectrometers are revolutionizing the way we use NMR and
lowering the cost drastically. Magnetic field cycling (MFC) experiments with precise timing …

Reversible Parahydrogen Induced Hyperpolarization of 15N in Unmodified Amino Acids Unraveled at High Magnetic Field

E Vaneeckhaute, JM Tyburn, JG Kempf… - Advanced …, 2023 - Wiley Online Library
Amino acids (AAs) and ammonia are metabolic markers essential for nitrogen metabolism
and cell regulation in both plants and humans. NMR provides interesting opportunities to …