Transmissible spongiform encephalopathies (TSEs) are inevitably lethal neurodegenerative
diseases that affect humans and a large variety of animals. The infectious agent responsible …

The prion (infectious protein) concept has evolved with the discovery of new self-
propagating protein states in organisms as diverse as mammals and fungi. The infectious …

Prions are proteins that adopt alternative conformations that become self-propagating; the
PrPSc prion causes the rare human disorder Creutzfeldt–Jakob disease (CJD). We report …

For more than 20 years, since it was first published in 1983 the Laboratory biosafety manual
has provided practical guidance on biosafety techniques for use in laboratories at all levels …

Despite the importance of the aberrant polymerization of Aβ in the early pathogenic cascade
of Alzheimer's disease, little is known about the induction of Aβ aggregation in vivo. Here we …

Parkinson's disease and related disorders are neuropathologically characterized by cellular
deposits of misfolded and aggregated α-synuclein in the CNS. Disease-associated α …

To reach the central nervous system (CNS), pathogens have to circumvent the wall of tightly
sealed endothelial cells that compose the blood–brain barrier. Neuronal projections that …

Chronic wasting disease (CWD) is an emerging prion disease of deer and elk. The risk of
CWD transmission to humans following exposure to CWD-infected tissues is unknown. To …

ABSTRACT α-Synuclein is a soluble, cellular protein that in a number of neurodegenerative
diseases, including Parkinson's disease and multiple system atrophy, forms pathological …

Chronic wasting disease (CWD) status and PrP genotypes were determined for a group of
133 wild white-tailed deer in a 780 acre enclosure in western Nebraska, USA …