Killing in the name of: T6SS structure and effector diversity

LP Allsopp, P Bernal - Microbiology, 2023 - microbiologyresearch.org
The life of bacteria is challenging, to endure bacteria employ a range of mechanisms to
optimize their environment, including deploying the type VI secretion system (T6SS). Acting …

Type VI Secretion System in Pathogenic Escherichia coli: Structure, Role in Virulence, and Acquisition

F Navarro-Garcia, F Ruiz-Perez, Á Cataldi… - Frontiers in …, 2019 - frontiersin.org
Bacterial pathogens utilize a myriad of mechanisms to invade mammalian hosts, damage
tissue sites, and evade the immune system. One essential strategy of Gram-negative …

Assembly and subcellular localization of bacterial type VI secretion systems

J Wang, M Brodmann, M Basler - Annual review of microbiology, 2019 - annualreviews.org
Bacteria need to deliver large molecules out of the cytosol to the extracellular space or even
across membranes of neighboring cells to influence their environment, prevent predation …

Cryo-EM structure and assembly of an extracellular contractile injection system

F Jiang, N Li, X Wang, J Cheng, Y Huang, Y Yang… - Cell, 2019 - cell.com
Contractile injection systems (CISs) are cell-puncturing nanodevices that share ancestry
with contractile tail bacteriophages. Photorhabdus virulence cassette (PVC) represents one …

Conserved and Diverse Traits of Adhesion Devices from Siphoviridae Recognizing Proteinaceous or Saccharidic Receptors

A Goulet, S Spinelli, J Mahony, C Cambillau - Viruses, 2020 - mdpi.com
Bacteriophages can play beneficial roles in phage therapy and destruction of food
pathogens. Conversely, they play negative roles as they infect bacteria involved in …

Subcellular localization of Type VI secretion system assembly in response to cell–cell contact

L Lin, R Capozzoli, A Ferrand, M Plum, A Vettiger… - The EMBO …, 2022 - embopress.org
Bacteria require a number of systems, including the type VI secretion system (T6SS), for
interbacterial competition and pathogenesis. The T6SS is a large nanomachine that can …

Atomic structures of an entire contractile injection system in both the extended and contracted states

A Desfosses, H Venugopal, T Joshi, J Felix… - Nature …, 2019 - nature.com
Contractile injection systems are sophisticated multiprotein nanomachines that puncture
target cell membranes. Although the number of atomic-resolution insights into contractile …

Uncovering the Secretion Systems of Acinetobacter baumannii: Structures and Functions in Pathogenicity and Antibiotic Resistance

P Li, S Zhang, J Wang, MM Al-Shamiri, B Han, Y Chen… - Antibiotics, 2023 - mdpi.com
Infections led by Acinetobacter baumannii strains are of great concern in healthcare
environments due to the strong ability of the bacteria to spread through different apparatuses …

Defending against the type six secretion system: beyond immunity genes

SJ Hersch, K Manera, TG Dong - Cell Reports, 2020 - cell.com
The bacterial type six secretion system (T6SS) delivers toxic effector proteins into
neighboring cells, but bacteria must protect themselves against their own T6SS. Immunity …

Immunity proteins of dual nuclease T6SS effectors function as transcriptional repressors

SK Yadav, A Magotra, S Ghosh, A Krishnan… - EMBO …, 2021 - embopress.org
Bacteria utilize type VI secretion system (T6SS) to deliver antibacterial toxins to target co‐
habiting bacteria. Here, we report that Burkholderia gladioli strain NGJ1 deploys certain …