Polymeric nanocapsules: A review on design and production methods for pharmaceutical purpose

AL Lima, T Gratieri, M Cunha-Filho, GM Gelfuso - Methods, 2022 - Elsevier
Polymeric nanocapsules have extensive application potential in medical, biological, and
pharmaceutical fields, and, therefore, much research has been dedicated to their production …

Colloidal stability and degradability of silica nanoparticles in biological fluids: A review

A da Cruz Schneid, LJC Albuquerque… - Journal of Sol-Gel …, 2022 - Springer
This review shows the most common and promising strategies to generate colloidally stable
silica nanoparticles (NPs) in simulated biological fluids and sheds light on the latest …

Brush conformation of polyethylene glycol determines the stealth effect of nanocarriers in the low protein adsorption regime

M Li, S Jiang, J Simon, D Paßlick, ML Frey… - Nano …, 2021 - ACS Publications
For nanocarriers with low protein affinity, we show that the interaction of nanocarriers with
cells is mainly affected by the density, the molecular weight, and the conformation of …

Circulating immunotherapy strategy based on pyroptosis and STING pathway: Mn-loaded paclitaxel prodrug nanoplatform against tumor progression and metastasis

B Wang, T Wang, T Jiang, S Li, L Zhang, X Zhao… - Biomaterials, 2024 - Elsevier
Immunotherapy has emerged as a promising strategy against tumors. However, its efficacy
is limited by low immunogenicity, poor antigen presentation, and inadequate lymphocyte …

Anti-PEG antibodies enriched in the protein corona of PEGylated nanocarriers impact the cell uptake

MFS Deuker, V Mailänder, S Morsbach… - Nanoscale …, 2023 - pubs.rsc.org
Poly (ethylene glycol)(PEG) is the gold standard used to reduce unspecific protein
adsorption and prolong nanocarrier circulation time. However, this stealth effect could be …

In situ characterization techniques of protein corona around nanomaterials

F Fu, D Crespy, K Landfester, S Jiang - Chemical Society Reviews, 2024 - pubs.rsc.org
Nanoparticles (NPs) inevitably interact with proteins upon exposure to biological fluids,
leading to the formation of an adsorption layer known as the “protein corona”. This corona …

Synthetic silica nano‐organelles for regulation of cascade reactions in multi‐compartmentalized systems

S Jiang, L Caire da Silva, T Ivanov… - Angewandte …, 2022 - Wiley Online Library
In eukaryotic cells, enzymes are compartmentalized into specific organelles so that different
reactions and processes can be performed efficiently and with a high degree of control. In …

Ultrasmall nanocapsules obtained by controlling Ostwald ripening

TP Doan‐Nguyen, S Jiang, K Koynov… - Angewandte Chemie …, 2021 - Wiley Online Library
We describe here a method to synthesize ultrasmall nanocapsules with a diameter of 6 nm,
exhibiting a well‐defined core–shell morphology. Remarkably, the nanocapules are …

Temperature, concentration, and surface modification influence the cellular uptake and the protein corona of polystyrene nanoparticles

J Oberländer, C Champanhac, R da Costa Marques… - Acta Biomaterialia, 2022 - Elsevier
The composition of the protein corona varies depending on several parameters and
influences the cellular fate of the nanocarriers. Here, we investigated the influence of three …

Current status of glucocorticoid usage in solid organ transplantation

S Dashti-Khavidaki, R Saidi… - World journal of …, 2021 - pmc.ncbi.nlm.nih.gov
Glucocorticoids (GCs) have been the mainstay of immunosuppressive therapy in solid organ
transplantation (SOT) for decades, due to their potent effects on innate immunity and tissue …