The complex relationship between large granular lymphocyte leukemia and rheumatic disease

T Marchand, T Lamy - Expert Review of Clinical Immunology, 2024 - Taylor & Francis
Introduction Large granular lymphocytic (LGL) leukemia is a rare lymphoproliferative
disorder characterized by an expansion of clonal T or NK lymphocytes. Neutropenia-related …

Aleukemic variant of T-cell large granular lymphocyte leukemia in patients with rheumatoid arthritis-diagnostically challenging subtype

V Gorodetskiy, A Sudarikov - Expert Review of Clinical …, 2024 - Taylor & Francis
Introduction The typical clinical manifestations of T-cell large granular lymphocyte (T-LGL)
leukemia are an increase in the number of large granular lymphocytes (LGLs) in the blood> …

[HTML][HTML] Analysis of Cytotoxic Granules and Constitutively Produced Extracellular Vesicles from Large Granular Lymphocytic Leukemia Cell Lines

L Ploeger, P Kaleja, A Tholey, M Lettau, O Janssen - Cells, 2024 - mdpi.com
Background: Large granular lymphocyte leukemias (LGLLs) are rare lymphoproliferative
malignancies caused by clonal expansion of granular lymphocytes. T-cell LGLL and natural …

Clonal hematopoiesis in large granular lymphocytic leukemia

N Kawashima, C Gurnari, C Bravo-Perez, Y Kubota… - Leukemia, 2024 - nature.com
Past studies described occasional patients with myeloid neoplasms (MN) and coexistent
large granular lymphocytic leukemia (LGLL) or T-cell clonopathy of unknown significance …

LGL clonal expansion and unexplained cytopenia: two clues don't make an evidence

G Calabretto, E Attardi, C Gurnari, G Semenzato… - Cancers, 2022 - mdpi.com
Simple Summary The clonal expansions of large granular lymphocytes are frequently
detected in a wide spectrum of hematological and immune diseases. This clinical overlap …

Gamma-delta T-cell large granular lymphocytic leukemia in the setting of rheumatologic diseases

V Gorodetskiy, Y Sidorova, B Biderman… - Frontiers in Cell and …, 2024 - frontiersin.org
Background T-cell leukemia originating from large granular lymphocytes (T-LGL leukemia)
is a rare lymphoid neoplasia characterized by clonal proliferation of large granular T …

HSP and CD279 gene expression as candidate biomarkers in symptomatic LGLL patients

G Talarico, A Franceschini, A Raveane, P Falvo… - Discover Oncology, 2024 - Springer
The clinical presentation of T-cell large granular lymphocytic leukemia (T-LGLL) is extremely
variable: 30% of patients have neutropenia with no associated symptoms, others present …

[HTML][HTML] Hepatosplenic T-cell lymphoma displays an original oyster-shell cytological pattern and a genomic profile distinct from that of γδ T-cell large granular …

A Desmares, S Bouzy, F Thonier, J Goustille… - …, 2024 - ncbi.nlm.nih.gov
Hepatosplenic T-cell lymphoma (HSTCL) is a highly aggressive T-cell neoplasm that arises
from the proliferation of gamma/delta T cells (γδT) infiltrating the liver, spleen, and bone …

How I diagnose large granular lymphocytic leukemia

M Shi, WG Morice - American Journal of Clinical Pathology, 2024 - academic.oup.com
Objectives Large granular lymphocytic leukemia (LGLL) represents a rare neoplasm of
mature T cells or natural killer (NK) cells, with an indolent clinical course. Diagnosing LGLL …

γδ and αβ T‐cell large granular lymphocytic leukaemia have similar characteristics and outcomes

R Cui, Y Yu, Y Li, Y Huang, J Sun, Y Yan… - British Journal of …, 2024 - Wiley Online Library
According to the 5th World Health Organization (WHO) classification, large granular
lymphocytic leukaemia (LGLL) is divided into two subtypes based on the lineage of the …