The most characteristic feature of microglial cells is their rapid activation in response to even
minor pathological changes in the CNS. Microglia activation is a key factor in the defence of …

During the past decade, mechanisms involved in the immune surveillance of the central
nervous system (CNS) have moved to the forefront of neuropathological research mainly …

The 'immune privilege'of the central nervous system (CNS) is indispensable for damage
limitation during inflammation in a sensitive organ with poor regenerative capacity. It is a …

Microglia, one of three glial cell types in the central nervous system (CNS), play an important
role as resident immunocompetent and phagocytic cells in the CNS in the event of injury and …

Damage to the central nervous system (CNS) leads to cellular changes not only in the
affected neurons but also in adjacent glial cells and endothelia, and frequently, to a …

The central nervous system (CNS) historically has been considered an immune-privileged
organ, lacking a lymphatic system and shielded from the circulatory system by the blood …

In 1900, summarizing his experiments with toxins and Ehrlich's earlier observations with
intravital dyes, the Berlin physician Lewandowski concluded that 'brain capillaries must hold …

The phenotypic differentiation of systemic macrophages that have infiltrated the central
nervous system, pericytes, perivascular macrophages, and the “real” resident microglial …

Macrophage/microglia (M∅) are the principal immune cells in the central nervous system
(CNS) concomitant with inflammatory brain disease and play a significant role in the host …

One of the characteristic features of microglia is their rapid activation in response to injury,
inflammation, neurodegeneration, infection, and brain tumors. This review focuses on the …