Efficacy and safety of anti-inflammatory agents in treatment of psychotic disorders–A comprehensive systematic review and meta-analysis

R Jeppesen, RHB Christensen, EMJ Pedersen… - Brain, behavior, and …, 2020 - Elsevier
Objective Antipsychotic effects of immunomodulating drugs have been suggested; however,
a thorough, comprehensive meta-analysis on the effect and safety of anti-inflammatory add …

Adjunctive agents to antipsychotics in schizophrenia: a systematic umbrella review and recommendations for amino acids, hormonal therapies and anti-inflammatory …

G Fond, J Mallet, M Urbach, ME Benros… - BMJ Ment …, 2023 - mentalhealth.bmj.com
Question This umbrella review and guidelines aimed to provide evidence to support the
rational choice of selected adjunctive therapies for schizophrenia. Study selection and …

The direct and long-term effects of raloxifene as adjunctive treatment for schizophrenia-spectrum disorders: a double-blind, randomized clinical trial

BA Brand, JN De Boer, MC Marcelis… - Schizophrenia …, 2023 - academic.oup.com
Background and hypothesis Several studies suggest that raloxifene, a selective estrogen
receptor modulator, improves symptoms and cognition in post-menopausal women with …

Risk for midlife psychosis in women: critical gaps and opportunities in exploring perimenopause and ovarian hormones as mechanisms of risk

KM Culbert, KN Thakkar, KL Klump - Psychological medicine, 2022 - cambridge.org
Women show a heightened risk for psychosis in midlife that is not observed in men. The
menopausal transition (ie perimenopause) and accompanying changes in ovarian …

Evidence-based recommendations for the pharmacological treatment of women with schizophrenia spectrum disorders

BA Brand, EJM Willemse, IMH Hamers… - Current Psychiatry …, 2023 - Springer
Abstract Purpose of Review Despite clear evidence that sex differences largely impact the
efficacy and tolerability of antipsychotic medication, current treatment guidelines for …

Estradiol and raloxifene as adjunctive treatment for women with schizophrenia: A meta‐analysis of randomized, double‐blind, placebo‐controlled trials

Z Li, Y Wang, Z Wang, L Kong, L Liu… - Acta Psychiatrica …, 2023 - Wiley Online Library
Objectives We conducted a comprehensive meta‐analysis of all available trials to evaluate
the efficacy and safety of estrogen and selective estrogen receptor modulators as adjunctive …

Estrogen and psychosis—a review and future directions

E Mu, C Gurvich, J Kulkarni - Archives of Women's Mental Health, 2024 - Springer
The link between sex hormones and schizophrenia has been suspected for over a century;
however, scientific evidence supporting the pharmacotherapeutic effects of exogenous …

The effect of menopause on antipsychotic response

A González-Rodríguez, JA Monreal, MV Seeman - Brain Sciences, 2022 - mdpi.com
Background: It has been hypothesized that, whenever estrogen levels decline, psychosis
symptoms in women increase. At menopause, this can happen in two main ways:(a) the loss …

Gender-specific approach in psychiatric diseases: because sex matters

A Franceschini, L Fattore - European journal of pharmacology, 2021 - Elsevier
In both animals and human beings, males and females differ in their genetic background
and hormonally driven behaviour and show sex-related differences in brain activity and …

Exploring a possible interplay between schizophrenia, oxytocin, and estrogens: a narrative review

D Papadea, C Dalla, DA Tata - Brain Sciences, 2023 - mdpi.com
Schizophrenia is characterized by symptoms of psychosis and sociocognitive deficits.
Considering oxytocin's antipsychotic and prosocial properties, numerous clinical, and …