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A transcriptome-wide association study of 229,000 women identifies new candidate susceptibility genes for breast cancer
The breast cancer risk variants identified in genome-wide association studies explain only a
small fraction of the familial relative risk, and the genes responsible for these associations …
small fraction of the familial relative risk, and the genes responsible for these associations …
[HTML][HTML] A causal variant rs3769823 in 2q33. 1 involved in apoptosis pathway leading to a decreased risk of non-small cell lung cancer
X Zhang, N Qin, J Fan, C Zhang, Q Sun… - Cancer Biology & …, 2022 - ncbi.nlm.nih.gov
Objective: Although our previous genome-wide association study (GWAS) has identified
chromosome 2q33. 1 as a susceptibility locus for non-small cell lung cancer (NSCLC), the …
chromosome 2q33. 1 as a susceptibility locus for non-small cell lung cancer (NSCLC), the …
Caspase 8 polymorphisms contribute to the prognosis of advanced lung adenocarcinoma patients after platinum-based chemotherapy
D Liu, W Xu, X Ding, Y Yang, Y Lu, K Fei… - Cancer biology & …, 2017 - Taylor & Francis
Lung cancer is the leading cause of cancer deaths in China, and about 60% of the cases are
diagnosed with histological adenocarcinoma. The c aspase 8 (CASP8) gene is a critical …
diagnosed with histological adenocarcinoma. The c aspase 8 (CASP8) gene is a critical …
Expression Quantitative Trait loci (QTL) in tumor adjacent normal breast tissue and breast tumor tissue
A Quiroz-Zárate, BJ Harshfield, R Hu, N Knoblauch… - PLoS …, 2017 - journals.plos.org
We investigate 71 single nucleotide polymorphisms (SNPs) identified in meta-analytic
studies of genome-wide association studies (GWAS) of breast cancer, the majority of which …
studies of genome-wide association studies (GWAS) of breast cancer, the majority of which …
Pooled genetic screens identify breast cancer risk genes involved in evasion from T cell-mediated killing
W Shi, Y Luo, JM Burrows, D Black, A Civitarese… - bioRxiv, 2024 - biorxiv.org
Genome-wide association studies have identified more than 220 loci associated with breast
cancer susceptibility. A major challenge is now to identify the effector genes with plausible …
cancer susceptibility. A major challenge is now to identify the effector genes with plausible …
Association of caspase 8 promoter variants and haplotypes with the risk of breast cancer and its molecular profile in an Iranian population: A case‐control study
Abstract Caspase 8 (CASP8) gene plays a key role in the regulation of apoptotic cell death.
Expression variation in this gene has been associated with the risk of breast cancer. The aim …
Expression variation in this gene has been associated with the risk of breast cancer. The aim …
Polymorphisms in the gene encoding caspase 8 may predict the response to first-line platinum-based chemotherapy in locally advanced or advanced non-small-cell …
M Szczyrek, R Mlak, A Szudy-Szczyrek… - Journal of Clinical …, 2021 - mdpi.com
Caspase 8 is a protein involved in the process of cell apoptosis, which may affect the
efficacy of anti-cancer treatment. The aim of our study was to determine the impact of …
efficacy of anti-cancer treatment. The aim of our study was to determine the impact of …
Mutational analysis of apoptotic genes in familial aggregation of hematological malignancies
WS Hamadou, R Mani, N Bouali, S Besbes, V Bourdon… - Bulletin du …, 2021 - Elsevier
Introduction Apoptosis deregulation have been associated to tumorigenesis process and
was highlighted as a prominent hallmark of cancer. Several mutations have been reported in …
was highlighted as a prominent hallmark of cancer. Several mutations have been reported in …