Background This position statement provides clinical recommendations for the assessment
of pain, level of sedation, iatrogenic withdrawal syndrome and delirium in critically ill infants …

OBJECTIVE: To develop comprehensive clinical practice guidelines for critically ill infants
and children, with specific attention to seven domains of care including pain …

Objectives: Analgesia and sedation are common therapies in pediatric critical care, and
rapid titration of these medications is associated with iatrogenic withdrawal syndrome. We …

Objectives: To evaluate current international practice in PICUs regarding components of the
“Assessing Pain, Both Spontaneous Awakening and Breathing Trials, Choice of Sedation …

We aim to develop evidence-based recommendations for intensivists caring for children
admitted to intensive care units and requiring analgesia and sedation. A panel of national …

Backgrounds Reports of increasing incidence rates of delirium in critically ill children are
reason for concern. We evaluated the measurement properties of the pediatric delirium …

What is known and objective Many critically ill patients are exposed to opioids and
benzodiazepines at high doses for prolonged periods, and upon discontinuation of these …

Background While several analgesia and sedation guidelines and protocols have been
developed and implemented for adults, there is still little evidence of clinical use of …

Purpose To compare daily sedation interruption plus protocolized sedation (DSI+ PS) to
protocolized sedation only (PS) in critically ill children. Methods In this multicenter …

Objectives: Withdrawal syndrome is an adverse reaction of analgesic and sedative therapy,
with a reported occurrence rate between 17% and 57% in critically ill children. Although …