It is well known that bone loss accompanies aging in both men and women and contributes
to skeletal fragility in the older population, but changes that occur to the bone tissue matrix …

Objectives The ability to determine human bone stiffness is of clinical relevance in many
fields, including bone quality assessment and orthopaedic prosthesis design. Stiffness can …

The accumulation of advanced glycation end-products (AGEs) in the organic matrix of bone
with aging and chronic disease such as diabetes is thought to increase fracture risk …

Water constitutes roughly a quarter of the cortical bone by volume yet can greatly influence
mechanical properties and tissue quality. There is a growing appreciation for how water can …

Recent in vitro evidence shows that glycosaminoglycans (GAGs) and proteoglycans (PGs) in
bone matrix may functionally be involved in the tissue-level toughness of bone. In this study …

In bone cutting, the tissue is exposed to necrosis due to temperature elevation, which can
significantly influence postoperative results in orthopaedic surgeries. This damage is usually …

Bone comprises mechanically different materials in a specific hierarchical structure.
Mineralized collagen fibrils (MCFs), represented by tropocollagen molecules and …

Primary osteoporosis is closely linked to hormone deficiency, which disrupts the balance of
bone remodeling. It affects postmenopausal women but also significantly impacts older men …

Abstract 3D printing offers the opportunity to design and make replacement parts to exacting
specifications when needed. This is particularly helpful for space applications where stand …

Bone features a remarkable combination of toughness and strength which originates from its
complex hierarchical structure and motivates its investigation on multiple length scales …