Genetic correlations of polygenic disease traits: from theory to practice
The genetic correlation describes the genetic relationship between two traits and can
contribute to a better understanding of the shared biological pathways and/or the causality …
contribute to a better understanding of the shared biological pathways and/or the causality …
Statistical methods to detect pleiotropy in human complex traits
S Hackinger, E Zeggini - Open biology, 2017 - royalsocietypublishing.org
In recent years pleiotropy, the phenomenon of one genetic locus influencing several traits,
has become a widely researched field in human genetics. With the increasing availability of …
has become a widely researched field in human genetics. With the increasing availability of …
Genomic structural equation modelling provides insights into the multivariate genetic architecture of complex traits
Genetic correlations estimated from genome-wide association studies (GWASs) reveal
pervasive pleiotropy across a wide variety of phenotypes. We introduce genomic structural …
pervasive pleiotropy across a wide variety of phenotypes. We introduce genomic structural …
Multi-trait analysis of genome-wide association summary statistics using MTAG
We introduce multi-trait analysis of GWAS (MTAG), a method for joint analysis of summary
statistics from genome-wide association studies (GWAS) of different traits, possibly from …
statistics from genome-wide association studies (GWAS) of different traits, possibly from …
Integrative approaches for large-scale transcriptome-wide association studies
Many genetic variants influence complex traits by modulating gene expression, thus altering
the abundance of one or multiple proteins. Here we introduce a powerful strategy that …
the abundance of one or multiple proteins. Here we introduce a powerful strategy that …
Shared genetic and experimental links between obesity-related traits and asthma subtypes in UK Biobank
Background Clinical and epidemiologic studies have shown that obesity is associated with
asthma and that these associations differ by asthma subtype. Little is known about the …
asthma and that these associations differ by asthma subtype. Little is known about the …
Identifying gene targets for brain-related traits using transcriptomic and methylomic data from blood
Understanding the difference in genetic regulation of gene expression between brain and
blood is important for discovering genes for brain-related traits and disorders. Here, we …
blood is important for discovering genes for brain-related traits and disorders. Here, we …
Genome-wide association analyses using electronic health records identify new loci influencing blood pressure variation
TJ Hoffmann, GB Ehret, P Nandakumar, D Ranatunga… - Nature …, 2017 - nature.com
Longitudinal electronic health records on 99,785 Genetic Epidemiology Research on Adult
Health and Aging (GERA) cohort individuals provided 1,342,814 systolic and diastolic blood …
Health and Aging (GERA) cohort individuals provided 1,342,814 systolic and diastolic blood …
Genome-wide association analyses of sleep disturbance traits identify new loci and highlight shared genetics with neuropsychiatric and metabolic traits
Chronic sleep disturbances, associated with cardiometabolic diseases, psychiatric disorders
and all-cause mortality,, affect 25–30% of adults worldwide. Although environmental factors …
and all-cause mortality,, affect 25–30% of adults worldwide. Although environmental factors …
Trans-ancestry meta-analyses identify rare and common variants associated with blood pressure and hypertension
High blood pressure is a major risk factor for cardiovascular disease and premature death.
However, there is limited knowledge on specific causal genes and pathways. To better …
However, there is limited knowledge on specific causal genes and pathways. To better …