[HTML][HTML] Dendrimers as nanocarriers for nucleic acid and drug delivery in cancer therapy

L Palmerston Mendes, J Pan, VP Torchilin - Molecules, 2017 - mdpi.com
Dendrimers are highly branched polymers with easily modifiable surfaces. This makes them
promising structures for functionalization and also for conjugation with drugs and DNA/RNA …

Dendrimers for drug delivery: An overview of its classes, synthesis, and applications

RJ Sarode, HS Mahajan - Journal of Drug Delivery Science and …, 2024 - Elsevier
The dendrimers in pharmaceuticals received much consideration from the scientific fraternity
due to their unique and versatile characteristics. Primarily, it includes monodispersity, three …

Dendrimers and hyperbranched structures for biomedical applications

E Pedziwiatr-Werbicka, K Milowska, V Dzmitruk… - European Polymer …, 2019 - Elsevier
The use of nanotechnology in biology and medicine has been marked by rapid progress of
these industries due to the emergence of new devices, supramolecular systems, structures …

Carbosilane dendrimers: Drug and gene delivery applications

N Rabiee, S Ahmadvand, S Ahmadi, Y Fatahi… - Journal of Drug Delivery …, 2020 - Elsevier
Carbosilane dendrimers are a particular type of dendrimer structure that has been used as
delivery vehicles for drugs and nucleic acids. They have a defined structure according to …

Dendrimers show promise for siRNA and microRNA therapeutics

V Dzmitruk, E Apartsin, A Ihnatsyeu-Kachan… - Pharmaceutics, 2018 - mdpi.com
The lack of an appropriate intracellular delivery system for therapeutic nucleic acids (TNAs)
is a major problem in molecular biology, biotechnology, and medicine. A relatively new class …

Poly (lysine) dendrimers form complexes with siRNA and provide its efficient uptake by myeloid cells: model studies for therapeutic nucleic acid delivery

M Gorzkiewicz, O Kopeć, A Janaszewska… - International Journal of …, 2020 - mdpi.com
The disruption of the cellular pathways of protein biosynthesis through the mechanism of
RNA interference has been recognized as a tool of great diagnostic and therapeutic …

Dendrimers as carriers for siRNA delivery and gene silencing: a review

J Wu, W Huang, Z He - The Scientific World Journal, 2013 - Wiley Online Library
RNA interference (RNAi) was first literaturally reported in 1998 and has become rapidly a
promising tool for therapeutic applications in gene therapy. In a typical RNAi process, small …

Nanoparticles in combating cancer: Opportunities and limitations: A brief review

E Pedziwiatr-Werbicka, K Horodecka… - Current Medicinal …, 2021 - ingentaconnect.com
Nanomedicine is a good alternative to traditional methods of cancer treatment but does not
solve all the limitations of oncology. Nanoparticles used in anticancer therapy can work as …

Biological properties of new viologen-phosphorus dendrimers

K Ciepluch, N Katir, A El Kadib, A Felczak… - Molecular …, 2012 - ACS Publications
Some biological properties of eight dendrimers incorporating both phosphorus linkages and
viologen units within their cascade structure or at the periphery were investigated for the first …

Anticancer siRNA cocktails as a novel tool to treat cancer cells. Part (B). Efficiency of pharmacological action

V Dzmitruk, A Szulc, D Shcharbin… - International journal of …, 2015 - Elsevier
This paper examines a perspective to use newly engineered nanomaterials as effective and
safe carriers for gene therapy of cancer. Three different groups of cationic dendrimers …