Estrogen receptors (ERs) regulate multiple complex physiological processes in humans.
Abnormal ER signaling may result in various disorders, including reproductive system …

Oestrogens and their receptors contribute broadly to physiology and diseases. In
premenopausal women, endogenous oestrogens protect against cardiovascular, metabolic …

The actions of estrogens and related estrogenic molecules are complex and multifaceted in
both sexes. A wide array of natural, synthetic, and therapeutic molecules target pathways …

Lung adenocarcinoma (LUAD) is one of the most common malignancies worldwide.
Combination chemotherapy with cisplatin (CDDP) plus pemetrexed (PEM) remains the …

Tumor-bearing experimental animals are essential for preclinical cancer drug development.
A broad range of tumor models is available, with the simplest and most widely used …

Estrogens mediate profound effects throughout the body and regulate physiological and
pathological processes in both women and men. The low prevalence of many diseases in …

Estrogen can elicit pleiotropic cellular responses via a diversity of estrogen receptors (ERs)—
mediated genomic and rapid non-genomic mechanisms. Unlike the genomic responses …

G protein-coupled receptors (GPCRs) belong to a superfamily of cell surface signalling
proteins that have a pivotal role in many physiological functions and in multiple diseases …

In mammals, the effects of estrogen are mainly mediated by two different estrogen receptors,
ERα and ERβ. These proteins are members of the nuclear receptor family, characterized by …

Using cDNA cloning strategies commonly employed for G protein-coupled receptors
(GPCR), GPCR-30 (GPR30), was isolated from mammalian cells before knowledge of its …