Six genetic families of the enzyme carbonic anhydrase (CA, EC 4.2. 1.1) were described to
date. Inhibition of CAs has pharmacologic applications in the field of antiglaucoma …

ABSTRACT Introduction Carbonic anhydrases (CAs, EC 4.2. 1.1) play a pivotal role in the
regulation of carbon dioxide, bicarbonate, and hydrogen ions within bacterial cells, ensuring …

Abstract Carbonic anhydrases (CAs, EC 4.2. 1.1) are metalloenzymes which catalyze a
simple but physiologically crucial reaction in all life Domains, the carbon dioxide hydration to …

Bacteria encode carbonic anhydrases (CAs, EC 4.2. 1.1) belonging to three different genetic
families, the α-, β-, and γ-classes. By equilibrating CO2 and bicarbonate, these …

The genome of the protozoan parasite Plasmodium falciparum, the causative agent of the
most lethal type of human malaria, contains a single gene annotated as encoding a carbonic …

Introduction: The carbonic anhydrases (CAs, EC 4.2. 1.1), a group of ubiquitously expressed
metalloenzymes, are involved in numerous physiological and pathological processes, as …

Introduction The clinically licensed drugs used as antibiotics prevent the microbial growth
interfering with the biosynthesis of proteins, nucleic acids, microorganism wall biosynthesis …

Abstract Carbonic anhydrase (CA, EC 4.2. 1.1) isoforms IX and XII are overexpressed in
many hypoxic tumors as a consequence of the hypoxia inducible factor (HIF) activation …

Introduction: Carbonic anhydrases (CAs, EC 4.2. 1.1) exist as five genetically distinct
families (α, β, γ, δ and ζ) in organisms all over the phylogenetic tree. Due to the ubiquity of …

Molecules containing the sulfonamide group (R-SO2NH2) as well as its structurally related
isosters, sulfamido (R-NH-SO2NH2) and sulfamato (RO-SO2NH2), constitute the most …