Hericium erinaceus is an edible and medicinal mushroom commonly used in traditional
Chinese medicine for centuries. Several studies have highlighted its therapeutic potential for …

Adequate levels of androgens (eugonadism), and specifically testosterone, are vital
compounds for male quality of life, longevity, and positive health outcomes. Testosterone …

The actions of androgens such as testosterone and dihydrotestosterone are mediated via
the androgen receptor (AR), a ligand-dependent nuclear transcription factor and member of …

Pulmonary hypertension (PH) encompasses a syndrome of diseases that are characterized
by elevated pulmonary artery pressure and pulmonary vascular remodeling and that …

Prostate and breast cancer are the two cancers with the highest incidence in men and
women, respectively. Here, we focus on the known biology of acquired resistance to …

Previous work in the endocrine and neuroendocrine fields has viewed the androgen
receptor (AR) as a transcription factor activated by testosterone or one of its many …

Testosterone is required for the maturation of male germ cells, the production of sperm and
thus male fertility. However, the mechanisms by which testosterone regulates spermatogenic …

The sex steroid hormones (SSHs) play several roles in regulation of various processes in
the cardiovascular, immune, muscular and neural systems. SSHs affect prenatal and …

The biological activity of androgens is thought to occur predominantly through binding to
intracellular androgen-receptors, a member of the nuclear receptor family, that interact with …

While patients with advanced prostate cancer initially respond favorably to androgen
ablation therapy, most experience a relapse of the disease within 1–2 years. Although …