The availability of public genomic resources can greatly assist biodiversity assessment,
conservation, and restoration efforts by providing evidence for scientifically informed …

The widespread occurrence of repetitive stretches of DNA in genomes of organisms across
the tree of life imposes fundamental challenges for sequencing, genome assembly, and …

The Ensembl gene annotation system has been used to annotate over 70 different
vertebrate species across a wide range of genome projects. Furthermore, it generates the …

The immune system is composed of two subsystems—the innate immune system and the
adaptive immune system. The innate immune system is the first to respond to pathogens and …

Plants have evolved an array of defenses against pathogens. However, mounting a defense
response frequently comes with the cost of a reduction in growth and reproduction, carrying …

The adaptive immune system arose 500 million years ago in ectothermic (cold-blooded)
vertebrates. Classically, the adaptive immune system has been defined by the presence of …

The innate immune system is the first line of defense against pathogens, which is initiated by
the recognition of pathogen-associated molecular patterns (PAMPs) and endogenous …

Although many de novo genome assembly projects have recently been conducted using
high-throughput sequencers, assembling highly heterozygous diploid genomes is a …

Abstract The Pacific oyster Crassostrea gigas belongs to one of the most species-rich but
genomically poorly explored phyla, the Mollusca. Here we report the sequencing and …

A fundamental question in developmental immunology is how bipotential thymocyte
precursors generate both CD4+ helper and CD8+ cytotoxic T cell lineages. The MHC …